Results 31 to 40 of about 2,733,956 (263)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Biotecnología en el Sector Agropecuario y Agroindustrial, 2009 El tomate (Lycopersicon esculentum), la hortaliza más sembrada en Colombia, es considerada una de las más importantes por su volumen de producción y demanda.
KATHERIN CASTRO +3 more
doaj
International Studies Journal, 2022 This paper examines the effect of training on career performance of Nigeria Security and Civil Defense Corps (NSCDC) Personnel in Kaduna state command to examine the impact and types of training required for effective career performance of NSCDC ...
LEKSHUM SUNDAY AMOS
doaj
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Existential core. Core directives Nature If you don't want to live, there won't be a continuation. Logic of the Great, Logic of the Wise ΧΡ ΩΝ Ил-Всевышний-Отец Богов :Бог-Сознания Вселенной выявляющий своё присутствие через осознанные свет и звуки , источник жизни и истины.
openaire +5 more sources
Cultura organizacional desde la teoría de Edgar Schein: Estudio fenomenológico
CLIO América, 2015 The article presents the study of a phenomenon of corporate life from the description of the organizational culture in three organizations of educational character in Santa Marta-Colombia, whose objective was guided to describe the organizational ...
Lilibeth Pedraza-Álvarez +3 more
doaj
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source