Astrocyte heterogeneity in brain metastases
Astrocytes emerge as pivotal regulators of metastatic colonization, survival, immune remodeling, and therapy response associated with an increasing heterogeneity that requires spatially and longitudinally resolved approaches to uncover regulatory programs and guide context‐specific therapies.
Carolina Hernández‐Oliver +2 more
wiley +1 more source
Where Are the Women in Basic Science Research? Gender Trends in Abstracts Presented at the Academic Surgical Congress. [PDF]
Obidike PC +6 more
europepmc +1 more source
From tumor‐centric to ecosystem‐based hypotheses in brain tumor research and care
Primary brain tumors, whether in adults or children, present a major challenge because of their dramatic prognosis and the ongoing lack of efficient therapeutic approaches. In recent years, a shift has occurred from tumor‐centric concepts to a more holistic view of these tumors as dynamic ecosystems.
Julie Gavard +8 more
wiley +1 more source
Access to Basic Sanitation Services and Associated Factors Among Rural Households in South Achefer District, Northwest Ethiopia: A Community-Based Cross-Sectional Study. [PDF]
Wondie Y +14 more
europepmc +1 more source
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Latent profile analysis of basic psychological need satisfaction and frustration in community-dwelling older adults and its associated factors. [PDF]
Yuhang C +8 more
europepmc +1 more source
Integrating Health Communication into Basic Medical Courses: A Qualitative Study for Enhancing Professional Competencies in Undergraduate Medical Students. [PDF]
Shi L +7 more
europepmc +1 more source
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
The impact of Medicaid expansion on coverage among those lacking housing basics, 2010-2019. [PDF]
Zhang C +3 more
europepmc +1 more source

