Results 101 to 110 of about 5,423,570 (303)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Separating the basic logics of the basic recurrences

open access: yesAnnals of Pure and Applied Logic, 2012
This paper shows that, even at the most basic level, the parallel, countable branching and uncountable branching recurrences of Computability Logic (see http://www.cis.upenn.edu/~giorgi/cl.html) validate different principles.
openaire   +3 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

PIC BASIC projects : 30 projects using PIC BASIC and PIC BASIC PRO /

open access: yes
A wealth of simple and advanced projects to show how PIC BASIC can be used to program the most widely used microcontroller on the market.Includes index.Print version record.Front Cover; PIC BASIC Projects: 30 Projects Using PIC BASIC and PIC BASIC PRO ...
Ibrahim, Dogan.
core  

Basic writing (un)written : a critical discourse analysis and genealogy of developmental English in Texas [PDF]

open access: yes, 2008
textThe purpose of this study was to investigate the discourses that author basic writing in Texas and question how instructors of basic writing at a community college are constructed as well as constructive through discursive practices.
Forell, Kristy Leigh Hamm, 1977-
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Trip Report on the Appalachian Adult Basic Education Special Project [PDF]

open access: yes, 1969
A rough draft of the trip report on the Appalachian Adult Basic Education Special Project submitted by Appalachian Adult Basic Education Demonstration Center circa ...
Appalachian Adult Basic Education Demonstration Center
core  

Of the basic right of access to justice
Do direito fundamental de acesso à justiça

open access: yesScientia Iuris, 2006
The access to justice is here studied as right basic. The article has for target the conceptualization of this guarantee and the identification of the main problems that presents. It analyzes the protection of the rights and offers proposals aiming at to
Mauro Vasni Paroski
doaj  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

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