Results 91 to 100 of about 1,150,444 (321)

Apathy and functional disability in behavioral variant frontotemporal dementia [PDF]

, 2018
Background Behavioral variant frontotemporal dementia (bvFTD) has profound consequences on patients and their families. In this multicenter study, we investigated the contribution of cognitive and neuropsychiatric factors to everyday function at ...
Alladi, Suvarna, Almaral-Carvalho, Viviane, Bahia, Valeria S., Balthazar, Marcio L.F., Brucki, Sonia M.D., Caramelli, Paulo, Damasceno, Benito, Guimaraes, Henrique C., Hodges, John R., Lima da Silva, Thais B., Mekala, Shailaja, Mioshi, Eneida, Nitrini, Ricardo, O’Connor, Claire M., Piguet, Olivier, Yassuda, Mônica S.   +15 more
core   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source

PROFILES OF RECREATIONAL ACTIVITIES OF DAILY LIVING (RADL) IN PATIENTS WITH MENTAL DISORDERS [PDF]

, 2009
Background: Activities of daily living, play a key role in the measurement of functional health as defined by the International Classification of Functioning, Disability and Health (ICF) and in prevention and treatment of mental or somatic illnesses ...
B. Geiselmann, G. Gehrke, Michael Linden
core   +1 more source

Delivering elder-care environments utilizing TV-channel based mechanisms [PDF]

, 2017
In this paper, we present a smart environment for elderly. What makes the development of such system challenging is that the concept of smartness for elderly brings to the extreme the idea of invisibility of the technology.
Chatzigiannakis, Ioannis, Dimitrios, Amaxilatis, Evdoxia, Vasileiou, Irene, Mavrommati, Vitaletti, Andrea   +4 more
core   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Does functional assessment of individuals aged 80-plus give rise to scientific discussion – considerations based on literature review

Annals of Agricultural and Environmental Medicine, 2019
Introduction and objective For many years, Europe has been struggling with the problem of an aging society. It is obvious that everyone would like to live longer while retaining good psycho-physical health and social activity.
Mariola Głowacka, Paulina Zabielska, Beata Haor, Beata Karakiewicz   +3 more
doaj   +1 more source

Categorisation of activities of daily living of lower limb amputees during short-term use of a portable kinetic recording system: a preliminary study [PDF]

, 2011
The purpose of this preliminary study was to determine the relevance of the categorisation of the load regime data to assess the functional output and usage of the prosthesis of lower limb amputees.
Frossard , Laurent, Pearcy , Mark, Stevenson , Nathan, Sullivan , John, Uden , Maggie   +4 more
core   +2 more sources

Behavioral Competence Among Community Dwelling Older People with Disability in Basic Activities of Daily Living.

Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics, 2000
This study observed the status of independence in behavioral competence among older people who have any disability in basic activities of daily living (BADL) living in a rural community in Japan. Study participants (N = 76) who were regarded as bedridden were surveyed by means of a questionnaire in July to August 1996.
T, Ishizaki, S, Watanabe, T, Suzuki, H, Shibata, H, Yoshida, S, Yasumura, N, Niino   +6 more
openaire   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source