Results 91 to 100 of about 1,153,423 (284)

The Effect of Medical Check-up and Basic Physical Activities Daily Living: Panel Study on among Indoesian Elderly 1993-2000

Makara Journal of Health Research, 2010
In the 21st Century, Indonesia becomes the fourth biggest ageing country in the World as reported by the Second World Assembly on Ageing (2002). The Indonesian Household Health Survey (2001) reported 88,9% of the elderly suffered from disability ...
Indang Trihandini
doaj   +1 more source

Predictors of functional decline in elderly patients undergoing transcatheter aortic valve implantation (TAVI) [PDF]

, 2017
Aims This study aimed to assess functional course in elderly patients undergoing transcatheter aortic valve implantation (TAVI) and to find predictors of functional decline.
Bischoff, Seraina, Carrel, Thierry, Gandon, Marianne, Huber, Christoph, Jüni, Peter, Moser, André, Neumann, Stephanie, Schoenenberger, Andreas W., Schoenenberger, Christa-Maria, Stortecky, Stefan, Stuck, Andreas E., Wenaweser, Peter, Windecker, Stephan   +12 more
core  

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Does functional assessment of individuals aged 80-plus give rise to scientific discussion – considerations based on literature review

Annals of Agricultural and Environmental Medicine, 2019
Introduction and objective For many years, Europe has been struggling with the problem of an aging society. It is obvious that everyone would like to live longer while retaining good psycho-physical health and social activity.
Mariola Głowacka, Paulina Zabielska, Beata Haor, Beata Karakiewicz   +3 more
doaj   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

The Effect of Group Movie Therapy on the Activities of Daily Living Among the Older Adults

Journal of Client-centered Nursing Care, 2019
Background: The daily living activities are among the essential components of life and reflect an important aspect of functional independence in older adults.
Narges Yaghini, Fatemeh Sadat Izadi-Avanji, Sedigheh Miranzadeh, Hossain Akbari   +3 more
doaj  

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

The silent victims of humanitarian crises and livelihood (in)security: a case study among migrants in two Chadian towns [PDF]

, 2009
Once a humanitarian disaster receives coverage in the global media, the international community usually mobilises to reduce the most severe consequences.
Bruijn, M., de, Djindil, N.S.
core   +3 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source