Results 121 to 130 of about 1,150,117 (291)

(In)dependence of elderly people at their home in performing basic activities of daily living

Rev Rene, 2013
We aimed to outline the (in)dependence in performing basic activities of daily living of elderly people at home; apply educational geronto-technology to minimize specific functional loss; identify functional changes of these people, after using educational geronto-technology.
Santos, Silvana Sidney Costa, Gautério, Daiane Porto, Vidal, Danielle Adriane Silveira, Rosa, Bibiane Moura da, Zortea, Bruna, Urquia, Bianca Silveira   +5 more
openaire   +3 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Profile identification via weighted related metric scaling : an application to dependent Spanish children [PDF]

Disability and dependency (lack of autonomy in performing common everyday actions) affect health status and quality of life, therefore they are significant public health issues.
Aurea Grané, Irene Albarrán, Pablo Alonso   +2 more
core  

[Functional deterioration of basic daily living activities after an emergency service consultation].

Anales de medicina interna (Madrid, Spain : 1984), 2000
To determine the incidence of functional decline of elderly patients discharged from an emergency department and to analized functional impairment as a risk of readmission.A prospective cohort aged 75 or older were followed up after discharge from an emergency department between 01-02-95 and 01-04-95.
J, Gutiérrez Rodríguez, C, Varela Suárez, M, Alonso Alvarez, J J, Solano Jaurrieta   +3 more
openaire   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The Spanish Long-term Care System. ENEPRI Research Report No. 88, 15 June 2010 [PDF]

, 2010
Launched in January 2009, ANCIEN is a research project that runs for a 44-month period and involves 20 partners from EU member states. The project principally concerns the future of long-term care (LTC) for the elderly in Europe and addresses two ...
Fernanda Gutierrez, Maria, Jimenez-Martin, Sergi, Vegas Sanchez, Raquel, Vilaplana, Cristina.   +3 more
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Associations Between Anemia and Dependence on Basic and Instrumental Activities of Daily Living in Older Women

BMC Geriatrics
Abstract Aim The aim of the present study was to examine the relationship between anemia and basic and instrumental activities of daily living in older female patients. Methods 540 older female outpatients were included. Anemia was defined as a hemoglobin below 12 g/dL.
Karismaz, Abdulkadir, Pasin, Ozge, Kara, Osman, Eren, Rafet, Smith, Lee, Doventas, Alper, Soysal, Pinar   +6 more
openaire   +4 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source