Results 111 to 120 of about 6,030,938 (261)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Enhanced kinetics in Cu-doped LiFePO4 cathodes due to local structural disorder

Communications Materials
The widespread adoption of LiFePO4 as a cathode material is hindered by its intrinsically low ionic and electronic conductivity. While transition metal doping is a recognized strategy to mitigate these limitations, the precise mechanistic underpinnings ...
Dharmendra Kumar, A. Tripathy, Manju Sharma, S. R. Sahu, Samanway Mohanta, Ashutosh Anand, Sreejith O. V, Ramaswamy Murugan, Sanjay Singh, Rajamani Raghunathan, V. G. Sathe, Surender Kumar Sharma, D. K. Shukla   +12 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Genetic parameters for diameter, basic density, fibre properties and cellulose content for Eucalyptus nitens

, 2001
Genetic parameters were estimated for stem diameter, basic density, fibre length, fibre coarseness and cellulose content from 12-year-old Eucalyptus nitens progeny trials in Tasmania.
Raymond, Carolyn A, Banham, Paul W, Kube, Peter D   +2 more
core  

Effects of B fertilization on biomass production and wood quality of young

Industrial Crops and Products
Boron (B) is a micronutrient closely linked to tree productivity and stem quality in eucalyptus, with important implications for industrial wood utilization. However, the field response of Corymbia citriodora subsp.
Maria Leidiane Reis Barreto, Adam da Cruz Rodrigues, Cassio Rafael Costa dos Santos, Felipe Tavares Lima, Gleydson Vinicius dos Santos Silveira, Huga Géssica Bento de Oliveira Sousa, Beatriz Regolão de Cresci, Paulo Henrique Müller da Silva, Humberto de Jesus Eufrade Junior, Mario Tommasiello Filho, José Leonardo de Moraes Gonçalves, Alexandre de Vicente Ferraz   +11 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Influence of wood basic density on acacia melanoxylon kraft process [PDF]

, 2008
Wood density is a complex physical property related to the anatomical structure and the chemical composition of wood and one of the most important wood quality factors.
Simões, Rogério, Anjos, O., Santos, António J.   +2 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source