Results 111 to 120 of about 5,804,591 (298)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Enhanced kinetics in Cu-doped LiFePO4 cathodes due to local structural disorder

Communications Materials
The widespread adoption of LiFePO4 as a cathode material is hindered by its intrinsically low ionic and electronic conductivity. While transition metal doping is a recognized strategy to mitigate these limitations, the precise mechanistic underpinnings ...
Dharmendra Kumar, A. Tripathy, Manju Sharma, S. R. Sahu, Samanway Mohanta, Ashutosh Anand, Sreejith O. V, Ramaswamy Murugan, Sanjay Singh, Rajamani Raghunathan, V. G. Sathe, Surender Kumar Sharma, D. K. Shukla   +12 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Relationship between volumetric shrinkage and basic density (empty circles) or corrected basic density (filled circles) in B. guianensis.

, 2016
Relationship between volumetric shrinkage and basic density (empty circles) or corrected basic density (filled circles) in B. guianensis.
Jacques Beauchêne (2578726), Bruno Clair (453838), Christophe Duplais (2143408), Julie Bossu (2578723), Yannick Estevez (125156)   +4 more
core   +1 more source

On the density of certain cohesive basic sequences [PDF]

Pacific Journal of Mathematics, 1972
openaire   +3 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

density-matching v1.0

, 2015
Codes for density-matching, a new approach for optimization under ...
Pranay Seshadri
core   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Influence of wood basic density on acacia melanoxylon kraft process [PDF]

, 2008
Wood density is a complex physical property related to the anatomical structure and the chemical composition of wood and one of the most important wood quality factors.
Simões, Rogério, Simões, R., Anjos, O., Santos, A., Santos, António J.   +4 more
core   +1 more source