Results 121 to 130 of about 15,589,079 (272)

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Basic life support and advanced cardiac life support knowledge and skills among medical interns before and after a training workshop

Studia Medyczne, 2020
Arash Forouzan, Hasan Barzegari, Mahnaz Attari, Ali Delirrooyfard   +3 more
doaj   +1 more source

FINDING EFFECTIVENESS OF TEACHING BASIC LIFE SUPPORT TO PARAMEDICS

Pakistan Armed Forces Medical Journal, 2014
Objective: To determine the impact of single setting basic life support courses to paramedics by analyzing their responses. Study Design: Cross sectional analytical study.
Maqsood Ahmed, Mumtaz Ahmad, Aamer Malak
doaj  

European Resuscitation Council Guidelines for Resuscitation 2015: Section 2. Adult basic life support and automated external defibrillation

, 2015
Olasveengen, Theresa, Gräsner, Jan-Thorsten, Ristagno, Giuseppe, Soar, Jasmeet, Raffay, Violetta, Handley, Anthony J., Smyth, Michael A., Monsieurs, Koen, Koster, Rudolph W., Castrén, Maaret, Graesner, Jan-Thorsten, Perkins, Gavin D., Wenzel, Volker, Monsieurs, Koenraad G.   +13 more
core   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Guidelines for basic life support

, 1992
Holmberg, S., Bossaert, L., Handley, A., Bahr, J., et al., Monsieurs, K.   +5 more
core   +1 more source

Preservation of Basic Life Support Competencies Among Certified First Responders. [PDF]

Healthcare (Basel)
Goričan I, Šorgo A, Strnad M.
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source