Results 31 to 40 of about 115,261,517 (234)

Fluid-particle dynamics of nasal drug delivery in a realistic human airway lung model

, 2022
Nasal drug delivery provides a rapid onset of therapeutic effects due to the nasal route's large surface area, high blood flow, and ease of accessibility.
Francis, Isabella, Rahman, M. Mizanur (R21384), Saha , Suvash C., Huang, Xinlei   +3 more
core  

Research on Aerodynamic Optimization Design of High Lift Airfoil Based on Deep Learning and MOEA/D

Taiyuan Ligong Daxue xuebao
Purposes Aiming at the performance conflict between optimization parameters in prior optimization method, a hybrid optimization model based on MOEA/D is proposed, which integrates CNN and genetic algorithm into MOEA/D framework to balance the correlation
SHEN Yongqiang, WANG Han, XIANG Jixin, LI Zhiqiang   +3 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Computational Fluid Dynamics Applied to Chemical Reaction Engineering La mécanique des fluides numérique appliquée au génie des réactions chimiques

Oil & Gas Science and Technology, 2006
Computational Fluid Dynamics (CFD) and its applications have developed quite rapidly during the last ten years. This fast growing hybrid branch of Mechanics and Mathematics is certainly to be considered as a potentially useful and efficient tool in the ...
Trambouze P.
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Machine Learning for Fluid Mechanics

, 2020
International audienceThe field of fluid mechanics is rapidly advancing, driven by unprecedentedvolumes of data from experiments, field measurements, and large-scale sim-ulations at multiple spatiotemporal scales.
Brunton, Steven, Koumoutsakos, Petros, Noack, Bernd   +2 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Fracture Mechanics Investigation of Structures with Defects [PDF]

, 2013
Fracture mechanics plays an important role in the material science, structure design and industrial production due to the failure of materials and structures are paid high attention in human activities.
Li, Yong <1985>
core   +1 more source