Results 91 to 100 of about 1,552,390 (331)

COVID-19 basic reproduction number and assessment of initial suppression policies in Costa Rica

Mathematical Modelling of Natural Phenomena, 2020
SARS-COV-2 is the most recent from a series of emerging pathogens stressing national health systems. Initially restricted to Hubei province in China, COVID-19, the disease caused by SARS-COV-2 has become pandemic, reaching almost every nation on our ...
L. F. Chaves, L. Hurtado, M. R. Rojas, M. Friberg, R. Rodríguez, M. L. Avila-Aguero   +5 more
semanticscholar   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Evaluating different epidemiological models with the identical basic reproduction number ℛ0

Journal of Biological Dynamics, 2020
Epidemiological models with the identical basic reproduction number $ \mathcal {R}_0 $ may behave differently on both short time scale and long time scale.
Fan Bai
doaj   +1 more source

MODEL MATEMATIKA PENYEBARAN PENYAKIT PULMONARY TUBERCULOSIS DENGAN PENGGUNAAN MASKER MEDIS

Barekeng, 2020
This research developed a model of tuberculosis disease spread using the SIR model with addition of the medical mask usage factor. First, we create a diagram of the tuberculosis disease spread compartment through contact between individuals with medical ...
Nur Inayah, Muhammad Manaqib, Nina Fitriyati, Ikhwal Yupinto   +3 more
doaj   +1 more source

Graphs with specified degree distributions, simple epidemics and local vaccination strategies

, 2007
Consider a random graph, having a pre-specified degree distribution F but other than that being uniformly distributed, describing the social structure (friendship) in a large community. Suppose one individual in the community is externally infected by an
Britton, Tom, Janson, Svante, Martin-Lof, Anders   +2 more
core   +3 more sources

Collocation of Next-Generation Operators for Computing the Basic Reproduction Number of Structured Populations

Journal of Scientific Computing, 2020
We contribute a full analysis of theoretical and numerical aspects of the collocation approach recently proposed by some of the authors to compute the basic reproduction number of structured population dynamics as spectral radius of certain infinite ...
D. Breda, T. Kuniya, J. Ripoll, R. Vermiglio   +3 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Estimates of the basic reproduction number for rubella using seroprevalence data and indicator-based approaches [PDF]

, 2021
Timos Papadopoulos, Emilia Vynnycky
openalex   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source