Results 71 to 80 of about 556,638 (273)

Basic Reproduction Number of Enterovirus 71 Coxsackievirus A16 and A6: Evidence from Outbreaks of Hand, Foot and Mouth Disease in China between 2011 and 2018.

Clinical Infectious Diseases, 2020
BACKGROUND Enterovirus 71 (EV-A71), Coxsackievirus A16 (CV-A16) and Coxsackievirus A6 (CV-A6) are common serotypes causing hand, foot, and mouth disease (HFMD).
Zhong Zhang, Yang Liu, Fengfeng Liu, M. Ren, Taoran Nie, J. Cui, Z. Chang, Z. Li   +7 more
semanticscholar   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Bifurcation and Sensitivity Analysis of a Malaria Model with Isolated Drug Resistant Population

Journal of Applied Sciences and Environmental Management, 2021
A malaria model with isolated drug resistant population after the first line of treatment is presented using six systems of first order nonlinear differential equations. The disease free equilibrium point and the basic reproduction number are determined.
AO Sangotola
doaj   +1 more source

Estimating the Basic Reproductive Number from Viral Sequence Data [PDF]

Molecular Biology and Evolution, 2011
Epidemiological processes leave a fingerprint in the pattern of genetic structure of virus populations. Here, we provide a new method to infer epidemiological parameters directly from viral sequence data. The method is based on phylogenetic analysis using a birth-death model (BDM) rather than the commonly used coalescent as the model for the ...
Stadler, Tanja, Kouyos, Roger, von Wyl, Viktor, Yerly, Sabine, Böni, Jürg, Bürgisser, Philippe, Klimkait, Thomas, Joos, Beda, Rieder, Philip, Xie, Dong, Günthard, Huldrych F., Drummond, Alexei J., Bonhoeffer, Sebastian, Swiss HIV Cohort Study   +13 more
openaire   +6 more sources

The basic reproduction number and prediction of the epidemic size of the novel coronavirus (COVID-19) in Shahroud, Iran

Epidemiology and Infection, 2020
The aim of this study was to estimate the basic reproduction number (R0) of COVID-19 in the early stage of the epidemic and predict the expected number of new cases in Shahroud in Northeastern Iran.
A. Khosravi, R. Chaman, M. Rohani-Rasaf, F. Zare, S. Mehravaran, M. Emamian   +5 more
semanticscholar   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

COVID-19 basic reproduction number and assessment of initial suppression policies in Costa Rica

Mathematical Modelling of Natural Phenomena, 2020
SARS-COV-2 is the most recent from a series of emerging pathogens stressing national health systems. Initially restricted to Hubei province in China, COVID-19, the disease caused by SARS-COV-2 has become pandemic, reaching almost every nation on our ...
L. F. Chaves, L. Hurtado, M. R. Rojas, M. Friberg, R. Rodríguez, M. L. Avila-Aguero   +5 more
semanticscholar   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The linear stability and basic reproduction numbers for autonomous FDEs

Discrete and Continuous Dynamical Systems - S, 2023
In this paper, we first prove the stability equivalence between a linear autonomous and cooperative functional differential equation (FDE) and its associated autonomous and cooperative system without time delay. Then we present the theory of basic reproduction number $\mathcal{R}_0$ for general autonomous FDEs.
openaire   +2 more sources

Collocation of Next-Generation Operators for Computing the Basic Reproduction Number of Structured Populations

Journal of Scientific Computing, 2020
We contribute a full analysis of theoretical and numerical aspects of the collocation approach recently proposed by some of the authors to compute the basic reproduction number of structured population dynamics as spectral radius of certain infinite ...
D. Breda, T. Kuniya, J. Ripoll, R. Vermiglio   +3 more
semanticscholar   +1 more source