Results 71 to 80 of about 11,455,933 (276)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Quantifying the relative effects of environmental and direct transmission of norovirus [PDF]

Royal Society Open Science, 2018
Norovirus is a common cause of outbreaks of acute gastroenteritis in health- and child-care settings, with serial outbreaks also frequently observed aboard cruise ships. The relative contributions of environmental and direct person-to-person transmission
S. Towers, J. Chen, C. Cruz, J. Melendez, J. Rodriguez, A. Salinas, F. Yu, Y. Kang   +7 more
doaj   +1 more source

The linear stability and basic reproduction numbers for autonomous FDEs

Discrete and Continuous Dynamical Systems - S, 2023
In this paper, we first prove the stability equivalence between a linear autonomous and cooperative functional differential equation (FDE) and its associated autonomous and cooperative system without time delay. Then we present the theory of basic reproduction number $\mathcal{R}_0$ for general autonomous FDEs.
openaire   +2 more sources

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Insights into Clustering Patterns in Romania’s 2020–2024 Measles Cases

Epidemiologia
Background and objectives: During an outbreak, measles cases tend to aggregate into increasingly bigger clusters that show specific characteristics, different from the non-cluster cases.
Valerian-Ionuț Stoian, Cătălin Pleșea-Condratovici, Mădălina Nicoleta Matei, Iulia Draghiev, Liliana Baroiu, Carmina Mușat, Mihaela Patriciu, Valerii Luțenco, Mariana Daniela Ignat, Mihaela Debita   +9 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Prediction of basic reproduction number.

, 2018
Reproduction number as a function of Mosquito bite rate and LLINs coverage, we observe that the optimum coverage window for falciparum malaria transmission is 80–90.
Abdulaziz Y. A. Mukhtar (5349266), Rachid Ouifki (136496), Allan E. Clark (2541568), Justin B. Munyakazi (5349269)   +3 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Mathematical model for the control of measles

Journal of Applied Sciences and Environmental Management, 2018
We proposed a mathematical model of measles disease dynamics with vaccination by considering the total number of recovered individuals either from natural recovery or recovery due to vaccination.
O.J. Peter, O.A. Afolabi, A.A. Victor, C.E. Akpan, F.A. Oguntolu   +4 more
doaj   +1 more source

The basic reproduction number in epidemic models with periodic demographics

Journal of Biological Dynamics, 2009
Patterns of contact in social behaviour and seasonality due to environmental influences often affect the spread and persistence of diseases. Models of epidemics with seasonality and patterns in the contact rate include time-periodic coefficients, making the systems nonautonomous.
Curtis L, Wesley, Linda J S, Allen
openaire   +2 more sources