Results 71 to 80 of about 1,163,093 (264)

Quantifying the relative effects of environmental and direct transmission of norovirus [PDF]

Royal Society Open Science, 2018
Norovirus is a common cause of outbreaks of acute gastroenteritis in health- and child-care settings, with serial outbreaks also frequently observed aboard cruise ships. The relative contributions of environmental and direct person-to-person transmission
S. Towers, J. Chen, C. Cruz, J. Melendez, J. Rodriguez, A. Salinas, F. Yu, Y. Kang   +7 more
doaj   +1 more source

ANALISIS KESTABILAN LOKAL TITIK EKUILIBRIUM MODEL EPIDEMI SEIV DENGAN PERTUMBUHAN LOGISTIK

Majalah Ilmiah Matematika dan Statistika, 2022
The SEIV model uses population growth which is assumed to follow logistical growth. The model is studied then analyzed. The analysis shows that the non-endemic (disease-free) equilibrium point is locally asymptotically stable when the basic reproduction ...
Joko Harianto, Inda Puspita Sari
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Insights into Clustering Patterns in Romania’s 2020–2024 Measles Cases

Epidemiologia
Background and objectives: During an outbreak, measles cases tend to aggregate into increasingly bigger clusters that show specific characteristics, different from the non-cluster cases.
Valerian-Ionuț Stoian, Cătălin Pleșea-Condratovici, Mădălina Nicoleta Matei, Iulia Draghiev, Liliana Baroiu, Carmina Mușat, Mihaela Patriciu, Valerii Luțenco, Mariana Daniela Ignat, Mihaela Debita   +9 more
doaj   +1 more source

Mathematical model for the control of measles

Journal of Applied Sciences and Environmental Management, 2018
We proposed a mathematical model of measles disease dynamics with vaccination by considering the total number of recovered individuals either from natural recovery or recovery due to vaccination.
O.J. Peter, O.A. Afolabi, A.A. Victor, C.E. Akpan, F.A. Oguntolu   +4 more
doaj   +1 more source

Modelling repeated epidemics with general infection kernels [PDF]

, 2004
An integral equation approach is taken to explore the characteristics of a general infectious disease in a homogeneous population. It is shown that the final size of the epidemic depends on the basic reproduction ratio for the infection and the ...
Mann, J., Roberts, M.
core  

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

The Basic Reproductive Number for Disease Systems with Multiple Coupled Heterogeneities [PDF]

Mathematical Biosciences, 2017
AbstractIn mathematical epidemiology, a well-known formula describes the impact of heterogeneity on the basic reproductive number,R0, for situations in which transmission is separable and for which there is one source of variation in susceptibility and one source of variation in infectiousness.
Lloyd, Alun L., Kitron, Uriel, Perkins, T. Alex, Vazquez-Prokopec, Gonzalo M., Waller, Lance A.   +4 more
openaire   +3 more sources