Results 51 to 60 of about 1,163,093 (264)
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
MODEL MATEMATIKA PENYEBARAN PENYAKIT PULMONARY TUBERCULOSIS DENGAN PENGGUNAAN MASKER MEDIS
Barekeng, 2020 This research developed a model of tuberculosis disease spread using the SIR model with addition of the medical mask usage factor. First, we create a diagram of the tuberculosis disease spread compartment through contact between individuals with medical ...
Nur Inayah +3 more
doaj +1 more source
Mathematical Modeling for Hospitalization due to Temperature Variations [PDF]
International Journal of Mathematical, Engineering and Management Sciences, 2019 Sudden changes in temperature occur due to ecological disturbances which results into global warming, volcanic eruption, depletion of ozone layer etc. This has become a crucial environmental and social issue all over the world.
Nita H. Shah +3 more
doaj +1 more source
Bifurcation and Sensitivity Analysis of a Malaria Model with Isolated Drug Resistant Population
Journal of Applied Sciences and Environmental Management, 2021 A malaria model with isolated drug resistant population after the first line of treatment is presented using six systems of first order nonlinear differential equations. The disease free equilibrium point and the basic reproduction number are determined.
AO Sangotola
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Evaluating different epidemiological models with the identical basic reproduction number ℛ0
Journal of Biological Dynamics, 2020 Epidemiological models with the identical basic reproduction number $ \mathcal {R}_0 $ may behave differently on both short time scale and long time scale.
Fan Bai
doaj +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
On the basic reproduction number in a random environment
Journal of Mathematical Biology, 2012 The concept of basic reproduction number R0 in population dynamics is studied in the case of random environments. For simplicity the dependence between successive environments is supposed to follow a Markov chain. R0 is the spectral radius of a next-generation operator.
/Bacaër, Nicolas, Khaladi, M.
openaire +5 more sources
Barekeng, 2023 This study discusses the SRV mathematical model of the rate of people refusing vaccination. The data used is primary data in the form of questionnaire data taken directly from the community in Pinrang district related to the rate of people who refuse ...
Syafruddin Side +3 more
doaj +1 more source