Results 61 to 70 of about 1,163,093 (264)
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Health Professionals and the Dynamics of COVID-19 in Manaus during the First Wave
Trends in Computational and Applied Mathematics, 2022 A model is made for the dynamics of the transmission of the new SARS-CoV-2 coronavirus, which caused the COVID-19 pandemic. This model is based on the Susceptible--Infectious--Recovered model with heterogeneity in the susceptible population and in the ...
R. C. Bassanezi +5 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Efficient numerical computation of the basic reproduction number for structured populations
Journal of Computational and Applied Mathematics, 2021 As widely known, the basic reproduction number plays a key role in weighing birth/infection and death/recovery processes in several models of population dynamics. In this general setting, its characterization as the spectral radius of next generation operators is rather elegant, but simultaneously poses serious obstacles to its practical determination.
Dimitri Breda +3 more
openaire +5 more sources
Graphs with specified degree distributions, simple epidemics and local vaccination strategies
, 2007 Consider a random graph, having a pre-specified degree distribution F but other than that being uniformly distributed, describing the social structure (friendship) in a large community. Suppose one individual in the community is externally infected by an
Britton, Tom +2 more
core +3 more sources
Modeling the Epidemic Outbreak and Dynamics of COVID-19 in Croatia
, 2020 The paper deals with a modeling of the ongoing epidemic caused by Coronavirus disease 2019 (COVID-19) on the closed territory of the Republic of Croatia.
cantó +6 more
core +1 more source
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Global stability of a distributed delayed viral model with general incidence rate
Open Mathematics, 2018 In this paper, we discussed a infinitely distributed delayed viral infection model with nonlinear immune response and general incidence rate. We proved the existence and uniqueness of the equilibria.
Ávila-Vales Eric +2 more
doaj +1 more source
On the Dynamics of Dengue Virus type 2 with Residence Times and Vertical Transmission
, 2016 A two-patch mathematical model of Dengue virus type 2 (DENV-2) that accounts for vectors' vertical transmission and between patches human dispersal is introduced. Dispersal is modeled via a Lagrangian approach.
Bichara, Derdei +4 more
core +2 more sources
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source