Results 61 to 70 of about 11,455,933 (276)
Estimating the Basic Reproductive Number from Viral Sequence Data [PDF]
Molecular Biology and Evolution, 2011 Epidemiological processes leave a fingerprint in the pattern of genetic structure of virus populations. Here, we provide a new method to infer epidemiological parameters directly from viral sequence data. The method is based on phylogenetic analysis using a birth-death model (BDM) rather than the commonly used coalescent as the model for the ...
Stadler, Tanja +13 more
openaire +6 more sources
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Barekeng, 2023 This study discusses the SRV mathematical model of the rate of people refusing vaccination. The data used is primary data in the form of questionnaire data taken directly from the community in Pinrang district related to the rate of people who refuse ...
Syafruddin Side +3 more
doaj +1 more source
Effects of agricultural practices on the basic reproduction number.
, 2021 Response of the basic reproduction number R0 (in bold and green) and its components (in blue) and (in red) to changes in (A) plant hosting capacity (h) under indirect (continuous line) and direct (dashed line) interference scenarios, (B) resident ...
Nik J. Cunniffe (8072018) +4 more
core +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Global stability of a distributed delayed viral model with general incidence rate
Open Mathematics, 2018 In this paper, we discussed a infinitely distributed delayed viral infection model with nonlinear immune response and general incidence rate. We proved the existence and uniqueness of the equilibria.
Ávila-Vales Eric +2 more
doaj +1 more source
Health Professionals and the Dynamics of COVID-19 in Manaus during the First Wave
Trends in Computational and Applied Mathematics, 2022 A model is made for the dynamics of the transmission of the new SARS-CoV-2 coronavirus, which caused the COVID-19 pandemic. This model is based on the Susceptible--Infectious--Recovered model with heterogeneity in the susceptible population and in the ...
R. C. Bassanezi +5 more
doaj +1 more source
The Basic Reproductive Number for Disease Systems with Multiple Coupled Heterogeneities [PDF]
Mathematical Biosciences, 2017 Abstract In mathematical epidemiology, a well-known formula describes the impact of heterogeneity on the basic reproductive number, R 0 , for situations in which transmission is separable and for which there is one source of variation in susceptibility and one ...
Lloyd, Alun L. +4 more
openaire +3 more sources
Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source