Results 41 to 50 of about 129,471 (246)

MODEL MATEMATIKA PENYEBARAN PENYAKIT PULMONARY TUBERCULOSIS DENGAN PENGGUNAAN MASKER MEDIS

Barekeng, 2020
This research developed a model of tuberculosis disease spread using the SIR model with addition of the medical mask usage factor. First, we create a diagram of the tuberculosis disease spread compartment through contact between individuals with medical ...
Nur Inayah, Muhammad Manaqib, Nina Fitriyati, Ikhwal Yupinto   +3 more
doaj   +1 more source

Mathematical Modeling for Hospitalization due to Temperature Variations [PDF]

International Journal of Mathematical, Engineering and Management Sciences, 2019
Sudden changes in temperature occur due to ecological disturbances which results into global warming, volcanic eruption, depletion of ozone layer etc. This has become a crucial environmental and social issue all over the world.
Nita H. Shah, Purvi M. Pandya, Moksha H. Satia, Foram A. Thakkar   +3 more
doaj   +1 more source

Efficient numerical computation of the basic reproduction number for structured populations

Journal of Computational and Applied Mathematics, 2021
As widely known, the basic reproduction number plays a key role in weighing birth/infection and death/recovery processes in several models of population dynamics. In this general setting, its characterization as the spectral radius of next generation operators is rather elegant, but simultaneously poses serious obstacles to its practical determination.
Dimitri Breda, Francesco Florian, Jordi Ripoll, Vermiglio Rossana   +3 more
openaire   +6 more sources

On the basic reproduction number in continuously structured populations [PDF]

Mathematical Methods in the Applied Sciences, 2020
In the framework of population dynamics, the basic reproduction number is, by definition, the expected number of offspring that an individual has during its lifetime. In constant and time periodic environments, it is calculated as the spectral radius of the so‐called next‐generation operator. In continuously structured populations defined in a Banach
Carles Barril, Àngel Calsina, Sílvia Cuadrado, Jordi Ripoll   +3 more
openaire   +4 more sources

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Evaluating different epidemiological models with the identical basic reproduction number ℛ0

Journal of Biological Dynamics, 2020
Epidemiological models with the identical basic reproduction number $ \mathcal {R}_0 $ may behave differently on both short time scale and long time scale.
Fan Bai
doaj   +1 more source

Bifurcation and Sensitivity Analysis of a Malaria Model with Isolated Drug Resistant Population

Journal of Applied Sciences and Environmental Management, 2021
A malaria model with isolated drug resistant population after the first line of treatment is presented using six systems of first order nonlinear differential equations. The disease free equilibrium point and the basic reproduction number are determined.
AO Sangotola
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source