Results 91 to 100 of about 1,163,093 (264)

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The linear stability and basic reproduction numbers for autonomous FDEs

Discrete and Continuous Dynamical Systems - S, 2023
In this paper, we first prove the stability equivalence between a linear autonomous and cooperative functional differential equation (FDE) and its associated autonomous and cooperative system without time delay. Then we present the theory of basic reproduction number $\mathcal{R}_0$ for general autonomous FDEs.
openaire   +2 more sources

Basic Reproduction Numbers for a Class of Reaction-Diffusion Epidemic Models

Bulletin of Mathematical Biology, 2020
We study the basic reproduction numbers for a class of reaction-diffusion epidemic models that are developed from autonomous ODE systems. We present a general numerical framework to compute such basic reproduction numbers; meanwhile, the numerical formulation provides useful insight into their characterizations.
Yang, Chayu, Wang, Jin
openaire   +3 more sources

The role of asymptomatic carriers on the dynamics of a lymphatic filariasis model incorporating control strategies

Results in Control and Optimization
This study presents a mathematical model to investigate the patterns of transmission in lymphatic filariasis. The model considers chronic, acute, and asymptomatic individuals and integrates key control strategies.
Mussa A. Stephano, Maranya M. Mayengo, Jacob I. Irunde   +2 more
doaj   +1 more source

Stability analysis of the endemic equilibrium state of an infection age-structured HIV/AIDS disease pandemic

Journal of Applied Sciences and Environmental Management, 2016
In this work we present an infection-age-structured mathematical model of AIDS disease dynamics and examine the endemic equilibrium state for stability.
T.T. Ashezua, I.J.M. Udoo, L.N. Ikpakyegh   +2 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

The basic reproduction number in epidemic models with periodic demographics

Journal of Biological Dynamics, 2009
Patterns of contact in social behaviour and seasonality due to environmental influences often affect the spread and persistence of diseases. Models of epidemics with seasonality and patterns in the contact rate include time-periodic coefficients, making the systems nonautonomous.
Curtis L, Wesley, Linda J S, Allen
openaire   +2 more sources

Mathematical model for the control of infectious disease

Journal of Applied Sciences and Environmental Management, 2018
We proposed a mathematical model of infectious disease dynamics. The model is a system of first order ordinary differential equations. The population is partitioned into three compartments of Susceptible S(t) , Infected I(t) and Recovered R(t).
O.J. Peter, O.B. Akinduko, F.A. Oguntolu, C.Y. Ishola   +3 more
doaj   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Analisa Kestabilan Bebas Penyakit pada Penyebaran Demam Berdarah Menggunakan Model Host – Vector [PDF]

, 2015
Tujuan dari penelitian ini adalah membentuk model matematika demam berdarah dengan mengasumsikan setelah sembuh dari sakit, maka dapat kembali rentan terhadap penyakit, dalam hal ini dibatasi untuk dua serotype.
Binatari, Nikenasih, Ratna Sari, Eminugroho   +1 more
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