Results 111 to 120 of about 30,745,353 (308)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 15 (1980)
, 1979 Twenty-Fourth Annual Meeting of the Arizona-Nevada Academy of Science and the Fifty-Sixth Annual Meeting Southwestern and Rocky Mountain Division American Association for the Advancement of Science / April 9-12, 1980 / Participating Societies: Arizona ...
Arizona-Nevada Academy of Science
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
ARE BASIC SCIENCE AND BIOTECHNOLOGY COMPLEMENTARY ACTIVITIES? [PDF]
Enhancing agricultural productivity depends greatly on the management of information flows between basic and applied research. A framework is developed to examine the mutual relationship between molecular biological research and agricultural ...
Buccola, Steven T., Xia, Yin
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Beijing Declaration on Basic Science
, 2019 Grundlagenforschung ist die Basis innovationsgetriebener Wirtschaftssysteme. Sie ist essentiell, um sich den globalen Herausforderungen zu stellen, die nur in internationaler Zusammenarbeit bewältigt werden können.
Zhong guo ke xue yuan +1 more
core +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 20 (1985)
, 1985 TWENTY NINTH ANNUAL MEETING / April 27, 1985 / Joint Meeting with the Pacific Division of the American Association for the Advancement of Science / Participating Societies: Arizona Junior Academy of Science, American Water Resources Association ...
Arizona-Nevada Academy of Science
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Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Proceedings of the Arizona-Nevada Academy of Science, Volume 08 (1973)
, 2014 SEVENTEENTH ANNUAL MEETING / May 4-5, 1973 / Participating Societies: Arizona-Nevada Junior Academy of Science, American Water Resources Association / University of Arizona / Tucson, ArizonaThis volume is part of the Arizona-Nevada Academy of Science ...
Arizona-Nevada Academy of Science
core
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source