Results 151 to 160 of about 8,297,014 (304)

Expert recommendations for setting and adjusting airway pressure release ventilation based on clinical experience and basic science evidence. [PDF]

Front Med (Lausanne)
Nieman GF, Bates JHT, Andrews PL, Rose L, Shiber J, Araos J, Aurelien L, Madden M, Manougian T, Satalin J, Varpula T, Al-Khalisy H, Markandaya M, Silva PL, da Fonseca Reis LF, Downs J, Camporota L, Habashi NM.   +17 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Emerging basic science concepts in geriatric fracture fixation and patient recovery. [PDF]

OTA Int
Mau M, Leucht P, Frihagen F, Duque G, Yoon R, Schemitsch E, Haller J.   +6 more
europepmc   +1 more source

PCSK9: From Basic Science Discoveries to Clinical Trials

Circulation Research, 2018
M. Shapiro, H. Tavori, S. Fazio
semanticscholar   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Making sense of low-complexity domains: The 2025 Lasker Basic Science Award. [PDF]

Proc Natl Acad Sci U S A
Kaelin WG.
europepmc   +1 more source

A critical narrative review of transfer of basic science knowledge in health professions education

Medical Education, 2018
Jean-Marie Castillo, Y. Park, I. Harris, Jeffrey J. H. Cheung, L. Sood, Maureen D Clark, K. Kulasegaram, R. Brydges, G. Norman, Nicole N. Woods   +9 more
semanticscholar   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

From basic science to prevention - the imperative for a convergence science approach for cardio- and cerebrovascular risk reduction in females with diabetes. [PDF]

J Clin Transl Sci
Villablanca AC, Smith BP, Wickman BE, Norman JE, Garrison SL, Nuthikattu S, Milenkovic D, Brown SD.   +7 more
europepmc   +1 more source

Endothelial Glycocalyx: Basic Science and Clinical Implications

Anaesthesia and Intensive Care, 2017
N. Pillinger, Pca Kam
semanticscholar   +1 more source