Results 171 to 180 of about 30,745,353 (308)

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Interview with Jeffrey A. Mensah, recipient of the 2026 Epilepsia Prize for basic science research. [PDF]

Epilepsia
Cendes F, Auvin S.
europepmc   +1 more source

Internal basic research, external basic research and the technological performance of pharmaceutical firms. [PDF]

We evaluate the impact of basic research on pharmaceutical firms’ technological performance, distinguishing between internal basic research and the exploitation of external basic research findings.
Belderbos, Rene, Leten, Bart, Kelchtermans, Stijn   +2 more
core  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

The sponsor-proxy model: Bridging basic science discovery and investigator-initiated clinical trials. [PDF]

J Clin Transl Sci
Liu X, Shank D, Lü J, Joshi M.
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

ILAE-YES global webinar series: Integrating clinical and basic science in epilepsy research. [PDF]

Epilepsia Open
Nome CG, Ravat P, Bartolomei F, de Curtis M, Di Sapia R, Galovic M, Gogou M, Imbach L, Jacobs J, Kobow K, Lam AD, Lisgaras CP, Micalizzi E, Nikalexi E, Noebels JL, Paz JT, Roopra AS, Shaaban S, Sheybani L, Sivathamboo S, Marti AS, Williamson A, Kuroda N.   +22 more
europepmc   +1 more source

Information Management Policy - King Abdullah University of Science and Technology

, 2011
Records, Information and Archies Management Policy of King Abdullah University of Science and TechnologyRecords, Information and Archives Management Policy of King Abdullah University of Science and ...
King Abdullah University of Science and Technology
core  

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Editorial: Music and medicine: from basic science to clinical practice. [PDF]

Front Neurosci
Lesiuk T, Viskontas IV, Galiatsatos P.
europepmc   +1 more source