Results 191 to 200 of about 1,653,806 (310)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

A Comprehensive Review of IL-10 and IL-10 Receptor Deficiencies: From Basic Science to Clinical Bedside. [PDF]

Clin Rev Allergy Immunol
Xiao J, Ye Z, Huang Y.
europepmc   +1 more source

Correction: Expert recommendations for setting and adjusting airway pressure release ventilation based on clinical experience and basic science evidence. [PDF]

Front Med (Lausanne)
Frontiers Production Office.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Fibroblast Growth Factor-7 and Hair Biology: Bridging Basic Science and Therapeutic Applications. [PDF]

Curr Issues Mol Biol
Huang HC, Hsieh WJ, Percec I, Chang TM.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Emerging basic science concepts in geriatric fracture fixation and patient recovery. [PDF]

OTA Int
Mau M, Leucht P, Frihagen F, Duque G, Yoon R, Schemitsch E, Haller J.   +6 more
europepmc   +1 more source

Basic Science in Psychiatry

Neurobiology of Disease, 2000
openaire   +3 more sources

Hepatocyte-like cell therapy for end-stage liver disease: From basic science to clinical application. [PDF]

Liver Res
Ge W, Wang Z, Chen Y, Tang X, Lou Z, Chen J, Xu X, Wang K.   +7 more
europepmc   +1 more source

'Sciences Basic to Psychiatry’ [PDF]

Bulletin of the Royal College of Psychiatrists, 1983
openaire   +1 more source