Results 201 to 210 of about 1,653,806 (310)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Expert recommendations for setting and adjusting airway pressure release ventilation based on clinical experience and basic science evidence. [PDF]

Front Med (Lausanne)
Nieman GF, Bates JHT, Andrews PL, Rose L, Shiber J, Araos J, Aurelien L, Madden M, Manougian T, Satalin J, Varpula T, Al-Khalisy H, Markandaya M, Silva PL, da Fonseca Reis LF, Downs J, Camporota L, Habashi NM.   +17 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

From the Bench to the Bedside and Back: Contemporary Applications of Basic Science to Innovations in Heart Transplantation. [PDF]

Can J Cardiol
Truby LK, Sharma G, Watson WD, Halloran PF, Hussain T, Madill-Thomsen KS, Esmailian G, Fung N, Peyster E, Moayedi Y, Rao V, Freed D, Bowles DE, Peltz M, Billia F.   +14 more
europepmc   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Making sense of low-complexity domains: The 2025 Lasker Basic Science Award. [PDF]

Proc Natl Acad Sci U S A
Kaelin WG.
europepmc   +1 more source

Basic Science and Cardiology I: Basics [PDF]

European Heart Journal, 2017
openaire   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Basic Science Research

Journal of Head & Neck Physicians and Surgeons, 2016
doaj  

From basic science to prevention - the imperative for a convergence science approach for cardio- and cerebrovascular risk reduction in females with diabetes. [PDF]

J Clin Transl Sci
Villablanca AC, Smith BP, Wickman BE, Norman JE, Garrison SL, Nuthikattu S, Milenkovic D, Brown SD.   +7 more
europepmc   +1 more source