MiR-29a-deficiency causes thickening of the basilar membrane and age-related hearing loss by upregulating collagen IV and laminin [PDF]
Frontiers in Cellular Neuroscience, 2023 Age-related hearing loss (ARHL) is the most common sensory degenerative disease and can significantly impact the quality of life in elderly people. A previous study using GeneChip miRNA microarray assays showed that the expression of miR-29a changes with
Peng Ma +12 more
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In Vivo Basilar Membrane Time Delays in Humans [PDF]
Brain Sciences, 2022 To date, objective measurements and psychophysical experiments have been used to measure frequency dependent basilar membrane (BM) delays in humans; however, in vivo measurements have not been made.
Marek Polak +5 more
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Measuring traveling wave velocity in the basilar membrane as a potential indicator of endolymphatic hydrops in definite Ménière’s disease: a narrative review [PDF]
Frontiers in NeurologyBackgroundThe pathological hallmark of Ménière’s disease is endolymphatic hydrops, which can lead to an increase in basilar membrane stiffness and, consequently, an acceleration of the traveling wave of sound.
Xingqian Shen +6 more
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The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea [PDF]
Scientific Reports, 2022 The prevailing theory of cochlear function states that outer hair cells amplify sound-induced vibration to improve hearing sensitivity and frequency specificity.
Wenxuan He +5 more
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Development and Characterization of a Biomimetic Totally Implantable Artificial Basilar Membrane System [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Cochlear implants (CIs) have become the standard treatment for severe-to-profound sensorineural hearing loss. Conventional CIs have some challenges, such as the use of extracorporeal devices, and high power consumption for frequency analysis. To overcome
Juyong Chung +7 more
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Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae [PDF]
eLife, 2018 Auditory sensory outer hair cells are thought to amplify sound-induced basilar membrane vibration through a feedback mechanism to enhance hearing sensitivity. For optimal amplification, the outer hair cell-generated force must act on the basilar membrane
Wenxuan He, David Kemp, Tianying Ren
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Numerical investigation of the basilar membrane vibration induced by the unsteady fluid flow in the human inner ear [PDF]
Archive of Mechanical Engineering, 2020 For a deeper understanding of the inner ear dynamics, a Finite-Element model of the human cochlea is developed. To describe the unsteady, viscous creeping flow of the liquid, a pressure-displacement-based Finite-Element formulation is used.
Philipp Wahl +2 more
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Minimum Phase Responses for the Basilar Membrane [PDF]
The Journal of the Acoustical Society of America, 1961 Appreciable experimental data exist for the amplitude of basilar membrane displacement as a function of sound frequency. Data on the phase of displacement vs frequency are relatively meager. At low frequencies the latter do not relate well to the phase predicted by recent mathematical models for membrane displacement.
James L. Flanagan, Carol M. Bird
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Responses to sound of the basilar membrane of the mammalian cochlea [PDF]
Current Opinion in Neurobiology, 1992 Recent evidence shows that the frequency-specific non-linear properties of auditory nerve and inner hair cell responses to sound, including their sharp frequency tuning, are fully established in the vibration of the basilar membrane. In turn, the sensitivity, frequency selectivity and non-linear properties of basilar membrane responses probably result ...
Mario A. Ruggero
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Design of Bionic Cochlear Basilar Membrane Acoustic Sensor for Frequency Selectivity Based on Film Triboelectric Nanogenerator [PDF]
Nanoscale Research Letters, 2018 Sensorineural hearing loss tops the list of most suffering disease for the sake of its chronic, spirit pressing, and handicapped features, which can happen to all age groups, from newborns to old folks.
Yudong Liu +5 more
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