Results 1 to 10 of about 73,190 (256)

Molecular heterogeneity of the non-human primate cochlea [PDF]

Nature Communications
Unraveling the intricate composition and function of the cochlea is paramount to comprehending the mechanisms underlying sound perception and the pathogenesis of auditory disorders.
Xin Chen, Yuwei Che, Jieyu Qi, Ming Cen, Shan Gao, Bin Zhu, Yiheng Ao, Xiangyu Ma, Cheng Cheng, Rongrong Guo, Xinlin Wang, Tian Shen, Jiheng Wu, Fanliang Kong, Wei Si, Yongchang Chen, Tao Tan, Ling Lu, Renjie Chai   +18 more
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Application of Curved MPR Algorithm to High Resolution 3 Dimensional T2 Weighted CISS Images for Virtual Uncoiling of Membranous Cochlea as an Aid for Cochlear Morphometry [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: With the use of various surgical techniques, types of implants, the preoperative assessment of cochlear dimensions is becoming increasingly relevant prior to cochlear implantation.
Joish Upendra Kumar, Y Kavitha
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Scanning laser optical tomography for in toto imaging of the murine cochlea. [PDF]

PLoS ONE, 2017
The mammalian cochlea is a complex macroscopic structure due to its helical shape and the microscopic arrangements of the individual layers of cells.
Lena Nolte, Nadine Tinne, Jennifer Schulze, Dag Heinemann, Georgios C Antonopoulos, Heiko Meyer, Hans Gerd Nothwang, Thomas Lenarz, Alexander Heisterkamp, Athanasia Warnecke, Tammo Ripken   +10 more
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Identification and Characterization of TMEM119-Positive Cells in the Postnatal and Adult Murine Cochlea

Brain Sciences, 2023
Transmembrane protein 119 (TMEM119) is expressed in a subset of resident macrophage cells of the brain and was proposed as a marker for native brain microglia. The presence of cells expressing TMEM119 in the cochlea has not yet been described.
Mohamed Bassiouni, Alina Smorodchenko, Heidi Olze, Agnieszka J. Szczepek   +3 more
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Monitoring blood-flow in the mouse cochlea using an endoscopic laser speckle contrast imaging system. [PDF]

PLoS ONE, 2018
Laser speckle contrast imaging (LSCI) enables continuous high-resolution assessment of microcirculation in real-time. We applied an endoscope to LSCI to measure cochlear blood-flow in an ischemia-reperfusion mouse model.
Tae Hoon Kong, Sunkon Yu, Byungjo Jung, Jin Sil Choi, Young Joon Seo   +4 more
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Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals

eLife, 2022
Reprogramming of the cochlea with hair-cell-specific transcription factors such as ATOH1 has been proposed as a potential therapeutic strategy for hearing loss.
Amrita A Iyer, Ishwar Hosamani, John D Nguyen, Tiantian Cai, Sunita Singh, Melissa M McGovern, Lisa Beyer, Hongyuan Zhang, Hsin-I Jen, Rizwan Yousaf, Onur Birol, Jenny J Sun, Russell S Ray, Yehoash Raphael, Neil Segil, Andrew K Groves   +15 more
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Variations in cochlea shape reveal different evolutionary adaptations in primates and rodents

Scientific Reports, 2023
The presence of a coiled cochlea is a unique feature of the therian inner ear. While some aspects of the cochlea are already known to affect hearing capacities, the full extent of the relationships between the morphology and function of this organ are ...
Joaquin del Rio, Roxana Taszus, Manuela Nowotny, Alexander Stoessel   +3 more
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Modeling cochlear micromechanics: hypotheses and models

Journal of Bio-X Research, 2019
. The cochlea plays an important role in the mammalian auditory system. Sound-induced cell motion in the cochlea is transformed into electrical signals that are then sent to primary auditory neurons.
Guangjian Ni, Jia Pang, Qi Zheng, Zihao Xu, Baolu Liu, Haiyu Zhang, Dong Ming   +6 more
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Steady streaming as a method for drug delivery to the inner ear

Scientific Reports, 2021
The inner ear, or cochlea, is a fluid-filled organ housing the mechanosensitive hair cells. Sound stimulation is relayed to the hair cells through waves that propagate on the elastic basilar membrane.
Laura Sumner, Jonathan Mestel, Tobias Reichenbach   +2 more
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Microstructural interactions contribute to the hotspot in the living cochlea

Current Research in Neurobiology, 2022
The mechanism of the active cochlea relies on a complex interaction between microstructures in the organ of Corti. A significant longitudinal vibration “hotspot” was recently observed in the high-frequency region of the living gerbil cochlea between the ...
Junpei Liu, Yanru Bai, Qianli Cheng, Shu Zheng, Stephen Elliott, Guangjian Ni   +5 more
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