Results 121 to 130 of about 27,811 (329)
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
A new approach to onset detection: towards an empirical grounding of theoretical and speculative ideologies of musical performance [PDF]
, 2016 This article assesses aspects of the current state of a project which aims, with the help of computers and computer software, to segment soundfiles of vocal melodies into their component notes, identifying precisely when the onset of each note occurs ...
Bailey, Nicholas +2 more
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Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?
Molecular Oncology, EarlyView.Current anticancer therapies are limited by the occurrence of resistance and undruggability of most proteins. Targeted protein degraders are novel, promising agents that trigger the selective degradation of previously undruggable proteins through the recruitment of the ubiquitin–proteasome machinery. Their mechanism of action raises exciting challenges,
Noé Herbel, Sophie Postel‐Vinay
wiley +1 more source
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Movies of Simulated Basilar-Membrane Motion [PDF]
, 1966 Robert C. Lummis +2 more
openalex +1 more source
Determination of ADP/ATP translocase isoform ratios in malignancy and cellular senescence
Molecular Oncology, EarlyView.The individual functions of three isoforms exchanging ADP and ATP (ADP/ATP translocases; ANTs) on the mitochondrial membrane remain unclear. We developed a method for quantitatively differentiating highly similar human ANT1, ANT2, and ANT3 using parallel reaction monitoring. This method allowed us to assess changes in translocase levels during cellular
Zuzana Liblova +18 more
wiley +1 more source
Trends in Hearing, 2015 The temporal masking curve (TMC) method is a behavioral technique for inferring human cochlear compression. The method relies on the assumptions that in the absence of compression, forward-masking recovery is independent of masker level and probe ...
Patricia Pérez-González +2 more
doaj +1 more source
Best Fit 3D Basilar Membrane Reconstruction to Routinely Assess the Scalar Position of the Electrode Array after Cochlear Implantation. [PDF]
J Clin Med, 2022 Torres R +9 more
europepmc +1 more source
Binaural Thresholds of Pulsive Signals and Place of Detection on the Basilar Membrane [PDF]
, 1966 James L. Flanagan, B. J. Watson
openalex +1 more source
Wave Propagation in 1-D Spiral geometry [PDF]
, 2014 In this article, we investigate the wave equation in spiral geometry and study the modes of vibrations of a one-dimensional (1-D) string in spiral shape.
Chatterjee, Deep, Nayak, Rajesh K.
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