Molecular Oncology, EarlyView.Breast cancer metastasis is associated with myeloid cell dysregulation and the lung‐specific accumulation of tumor‐supportive Gr1+ cells. Gr1+ cells support metastasis, in part, through a CHI3L1‐mediated mechanism, which can be targeted and inhibited with cargo‐free, polymeric nanoparticles.
Jeffrey A. Ma +9 more
wiley +1 more source
Analysis of a Dynamic Response of the Cochlea Using Fluid-Structure Interaction Model
Engineering Transactions, 2016 A one-dimensional (1D) model of the cochlea of the inner ear has been built and validated against the previously built three-dimensional (3D) fluid-structure interaction (FSI) model of the cochlea.
Konrad KAMIENIECKI +2 more
doaj +1 more source
Basilar membrane motion in the alligator lizard: Its relation to tonotopic organization and frequency selectivity [PDF]
, 1979 William T. Peake, A. Ling
openalex +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Asymmetric vibrations in the organ of Corti by outer hair cells measured from excised gerbil cochlea
Communications BiologyPending questions regarding cochlear amplification and tuning are hinged upon the organ of Corti (OoC) active mechanics: how outer hair cells modulate OoC vibrations.
Wei-Ching Lin +3 more
doaj +1 more source
Inner hair cell stereocilia displacement in response to focal stimulation of the basilar membrane in the ex vivo gerbil cochlea. [PDF]
Hear Res, 2021 Zosuls A, Rupprecht LC, Mountain DC.
europepmc +1 more source
Two-tone interactions in a nonlinear model of the basilar membrane [PDF]
, 1978 Yasuyuki Iso, Hiroto Sakamoto
openalex +1 more source
Molecular Oncology, EarlyView.The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine +10 more
wiley +1 more source
Magnetic Steering of Robotically Inserted Lateral-wall Cochlear-implant Electrode Arrays Reduces Forces on the Basilar Membrane In Vitro. [PDF]
Otol Neurotol, 2021 Hendricks CM +8 more
europepmc +1 more source
Laser interferometric measurements of basilar membrane vibrations in cats using a round window approach [PDF]
, 1981 Shyam M. Khanna, D. G. B. Leonard
openalex +1 more source