Results 141 to 150 of about 21,884 (318)

Basilar membrane resonance in the cochlea of the mustached bat. [PDF]

, 1995
Manfred Kössl, Ian J. Russell
openalex   +1 more source

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Bioinspired Suspended Sensing Membrane Array with Modulable Wedged‐Conductive Channels for Crosstalk‐Free and High‐Resolution Detection

Advanced Science
High spatial‐resolution detection is essential for biomedical applications and human‐machine interaction. However, as the sensor array density increases, the miniaturization will lead to interference between adjacent units and deterioration in sensing ...
Haixuan Luo, Xiaoliang Chen, Sheng Li, Jinbin Xu, Xiangming Li, Hongmiao Tian, Chunhui Wang, Bo Li, Manman Zhang, Bai Sun, Juan He, Jinyou Shao   +11 more
doaj   +1 more source

The effect of efferent stimulation on basilar membrane displacement in the basal turn of the guinea pig cochlea [PDF]

, 1996
Euan Murugasu, Ian J. Russell
openalex   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Emilin 2 promotes the mechanical gradient of the cochlear basilar membrane and resolution of frequencies in sound. [PDF]

Sci Adv, 2020
Russell IJ, Lukashkina VA, Levic S, Cho YW, Lukashkin AN, Ng L, Forrest D.   +6 more
europepmc   +1 more source

Multiple Modes of Motion for the Effectiveness of Outer Hair Cells at High Frequencies [PDF]

arXiv
Outer hair cells (OHCs) are essential for the sensitivity and frequency specificity of the mammalian ear. To perform this function, OHCs need to amplify the motion of the basilar membrane (BM), which is much stiffer than themselves. If OHCs and the BM are components of a single oscillator, this impedance mismatch seriously limits the effectiveness of ...
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

Semi‐supervised classification of fundus images combined with CNN and GCN

Journal of Applied Clinical Medical Physics, Volume 23, Issue 12, December 2022., 2022
Abstract Purpose Diabetic retinopathy (DR) is one of the most serious complications of diabetes, which is a kind of fundus lesion with specific changes. Early diagnosis of DR can effectively reduce the visual damage caused by DR. Due to the variety and different morphology of DR lesions, automatic classification of fundus images in mass screening can ...
Sixu Duan, Pu Huang, Min Chen, Ting Wang, Xiaolei Sun, Meirong Chen, Xueyuan Dong, Zekun Jiang, Dengwang Li   +8 more
wiley   +1 more source

D-Galactose-induced oxidative stress and mitochondrial dysfunction in the cochlear basilar membrane: an in vitro aging model. [PDF]

Biogerontology, 2020
Guo B, Guo Q, Wang Z, Shao JB, Liu K, Du ZD, Gong SS.   +6 more
europepmc   +1 more source