MiR-29a-deficiency causes thickening of the basilar membrane and age-related hearing loss by upregulating collagen IV and laminin [PDF]
Frontiers in Cellular Neuroscience, 2023 Age-related hearing loss (ARHL) is the most common sensory degenerative disease and can significantly impact the quality of life in elderly people. A previous study using GeneChip miRNA microarray assays showed that the expression of miR-29a changes with
Peng Ma +12 more
doaj +4 more sources
In Vivo Basilar Membrane Time Delays in Humans [PDF]
Brain Sciences, 2022 To date, objective measurements and psychophysical experiments have been used to measure frequency dependent basilar membrane (BM) delays in humans; however, in vivo measurements have not been made. This study aimed to measure BM delays by performing intracochlear electrocochleography in cochlear implant recipients.
Marek Polak +5 more
doaj +5 more sources
Design of Bionic Cochlear Basilar Membrane Acoustic Sensor for Frequency Selectivity Based on Film Triboelectric Nanogenerator [PDF]
Nanoscale Research Letters, 2018 Sensorineural hearing loss tops the list of most suffering disease for the sake of its chronic, spirit pressing, and handicapped features, which can happen to all age groups, from newborns to old folks.
Yaxing Zhu, Yang Zhang, Junyi Zhai
exaly +4 more sources
Measuring traveling wave velocity in the basilar membrane as a potential indicator of endolymphatic hydrops in definite Ménière’s disease: a narrative review [PDF]
Frontiers in NeurologyBackgroundThe pathological hallmark of Ménière’s disease is endolymphatic hydrops, which can lead to an increase in basilar membrane stiffness and, consequently, an acceleration of the traveling wave of sound.
Xingqian Shen +6 more
doaj +3 more sources
Theoretical and experimental study on traveling wave propagation characteristics of artificial basilar membrane [PDF]
Scientific ReportsThe traveling wave phenomenon in the artificial basilar membrane (ABM) plays a crucial role in the frequency selectivity and electromechanical signal generation of cochlear implants.
Jie Shan +3 more
doaj +3 more sources
The reticular lamina and basilar membrane vibrations in the transverse direction in the basal turn of the living gerbil cochlea [PDF]
Scientific Reports, 2022 The prevailing theory of cochlear function states that outer hair cells amplify sound-induced vibration to improve hearing sensitivity and frequency specificity.
Wenxuan He +5 more
doaj +2 more sources
Development and Characterization of a Biomimetic Totally Implantable Artificial Basilar Membrane System [PDF]
Frontiers in Bioengineering and Biotechnology, 2021 Cochlear implants (CIs) have become the standard treatment for severe-to-profound sensorineural hearing loss. Conventional CIs have some challenges, such as the use of extracorporeal devices, and high power consumption for frequency analysis. To overcome
Juyong Chung +7 more
doaj +2 more sources
Timing of the reticular lamina and basilar membrane vibration in living gerbil cochleae [PDF]
eLife, 2018 Auditory sensory outer hair cells are thought to amplify sound-induced basilar membrane vibration through a feedback mechanism to enhance hearing sensitivity. For optimal amplification, the outer hair cell-generated force must act on the basilar membrane
Wenxuan He, David Kemp, Tianying Ren
doaj +2 more sources
Numerical investigation of the basilar membrane vibration induced by the unsteady fluid flow in the human inner ear [PDF]
Archive of Mechanical Engineering, 2020 For a deeper understanding of the inner ear dynamics, a Finite-Element model of the human cochlea is developed. To describe the unsteady, viscous creeping flow of the liquid, a pressure-displacement-based Finite-Element formulation is used.
Philipp Wahl +2 more
doaj +3 more sources
Mathematical modeling of the radial profile of basilar membrane vibrations in the inner ear [PDF]
, 2003 Motivated by recent experimental results we seek an explanation of asymmetry in the radial profile of basilar membrane vibrations in the inner ear. We study a sequence of one-dimensional beam models which take into account variations in the bending ...
Champneys, AR +3 more
core +2 more sources