Results 51 to 60 of about 21,884 (318)

SIMULATION OF A COCHLEA OF AN INTERIOR EAR OF THE HUMAN

Medična Informatika ta Inženerìâ, 2012
There was conducted the simulations of a cochlea of an interior ear of the human by means of a long line. The following regularities of operation of a cochlea were determined: without the count of flexibilities Reissner's and basilar membranes swing ...
S. A. Naida, О. A. Zubchenko
doaj   +1 more source

A histidine‐rich extension of the mitochondrial F0 subunit ATP6 from the ice worm Mesenchytraeus solifugus increases ATP synthase activity in bacteria

FEBS Letters, EarlyView.
The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley, Daniel H. Shain, Eric A. Klein   +2 more
wiley   +1 more source

Nonlinear cochlear mechanics without direct vibration-amplification feedback

Physical Review Research, 2020
Recent in vivo recordings from the mammalian cochlea indicate that although the motion of the basilar membrane appears actively amplified and nonlinear only at frequencies relatively close to the peak of the response, the internal motions of the organ of
Alessandro Altoè, Christopher A. Shera
doaj   +1 more source

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source

A FPGA Implementation of the CAR-FAC Cochlear Model

Frontiers in Neuroscience, 2018
This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC)
Ying Xu, Chetan S. Thakur, Ram K. Singh, Tara Julia Hamilton, Runchun M. Wang, André van Schaik   +5 more
doaj   +1 more source

An immersed boundary model of the cochlea with parametric forcing [PDF]

SIAM Journal on Applied Mathematics, 75(3):1065-1089, 2015, 2015
The cochlea or inner ear has a remarkable ability to amplify sound signals. This is understood to derive at least in part from some active process that magnifies vibrations of the basilar membrane (BM) and the cochlear partition in which it is embedded, to the extent that it overcomes the effect of viscous damping from the surrounding cochlear fluid ...
arxiv   +1 more source

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

FEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher, Paula Armina V. Buco, Jia Q. Truong, Paul A. Ramsland, Monique F. Smeets, Carl R. Walkley, Jessica K. Holien   +6 more
wiley   +1 more source

A model for the nonlinear mechanism responsible for cochlear amplification

Mathematical Biosciences and Engineering, 2014
A nonlinear model for the mechanism responsible for the amplification of the sound wave in the ear is derived using the geometric and material properties of the system.
Kimberly Fessel, Mark H. Holmes
doaj   +1 more source

Impact of endolymphatic hydrops on DPOAE in subjects with normal to mild hearing loss

Laryngoscope Investigative Otolaryngology, 2023
Objective The increased endolymph volume affects a shift in the organ of Corti and basilar membrane in ears with endolymphatic hydrops (EH), which might affect distortion‐product otoacoustic emissions (DPOAE) by altering the operating point of the outer ...
Kei Inagaki, Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Yukari Fukunaga, Daisuke Hara, Shinji Naganawa, Michihiko Sone   +7 more
doaj   +1 more source

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

FEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source