Results 81 to 90 of about 27,811 (329)

Nonlinear cochlear mechanics without direct vibration-amplification feedback

Physical Review Research, 2020
Recent in vivo recordings from the mammalian cochlea indicate that although the motion of the basilar membrane appears actively amplified and nonlinear only at frequencies relatively close to the peak of the response, the internal motions of the organ of
Alessandro Altoè, Christopher A. Shera
doaj   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Mathematical model for the basilar membrane as a two dimensional plate

Electronic Journal of Differential Equations, 1999
In this paper we present two mathematical models for the basilar membrane. In the first model the membrane is represented as an annular region. In the second model the basilar membrane is treated as a rectangular region.
H. Y. Alkahby
doaj  

The spatial buildup of nonlinear compression in the cochlea

Frontiers in Cellular Neuroscience
In the mammalian cochlea, the transduction from vibrations to inner hair cell receptor currents is preceded by a stage of mechanical pre-processing that involves a rapid, strongly nonlinear compression.
Kostas Kondylidis, Kostas Kondylidis, Anna Vavakou, Anna Vavakou, Marcel van der Heijden   +4 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Impact of endolymphatic hydrops on DPOAE in subjects with normal to mild hearing loss

Laryngoscope Investigative Otolaryngology, 2023
Objective The increased endolymph volume affects a shift in the organ of Corti and basilar membrane in ears with endolymphatic hydrops (EH), which might affect distortion‐product otoacoustic emissions (DPOAE) by altering the operating point of the outer ...
Kei Inagaki, Tadao Yoshida, Masumi Kobayashi, Satofumi Sugimoto, Yukari Fukunaga, Daisuke Hara, Shinji Naganawa, Michihiko Sone   +7 more
doaj   +1 more source

Auditory neuroscience: Development, transduction and integration [PDF]

, 2000
Hearing underlies our ability to locate sound sources in the environment, our appreciation of music, and our ability to communicate. Participants in the National Academy of Sciences colloquium on Auditory Neuroscience: Development, Transduction, and ...
Hudspeth, A. J., Konishi, Masakazu
core  

A frequency-selective feedback model of auditory efferent suppression and its implications for the recognition of speech in noise [PDF]

, 2012
The potential contribution of the peripheral auditory efferent system to our understanding of speech in a background of competing noise was studied using a computer model of the auditory periphery and assessed using an automatic speech recognition system.
Brown, G, Clark, N, Juergens, T, Meddis, R   +3 more
core   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

A mechanoelectrical mechanism for detection of sound envelopes in the hearing organ

Nature Communications, 2018
The sound envelope is important for speech perception. Here, the authors look at mechanisms by which the sound envelope is encoded, finding that it arises from distortion produced by mechanoelectrical transduction channels.
Alfred L. Nuttall, Anthony J. Ricci, George Burwood, James M. Harte, Stefan Stenfelt, Per Cayé-Thomasen, Tianying Ren, Sripriya Ramamoorthy, Yuan Zhang, Teresa Wilson, Thomas Lunner, Brian C. J. Moore, Anders Fridberger   +12 more
doaj   +1 more source