A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
A FPGA Implementation of the CAR-FAC Cochlear Model
Frontiers in Neuroscience, 2018 This paper presents a digital implementation of the Cascade of Asymmetric Resonators with Fast-Acting Compression (CAR-FAC) cochlear model. The CAR part simulates the basilar membrane's (BM) response to sound. The FAC part models the outer hair cell (OHC)
Ying Xu +5 more
doaj +1 more source
By dawn or dusk—how circadian timing rewrites bacterial infection outcomes
FEBS Letters, EarlyView.The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo +2 more
wiley +1 more source
SIMULATION OF A COCHLEA OF AN INTERIOR EAR OF THE HUMAN
Medična Informatika ta Inženerìâ, 2012 There was conducted the simulations of a cochlea of an interior ear of the human by means of a long line. The following regularities of operation of a cochlea were determined: without the count of flexibilities Reissner's and basilar membranes swing ...
S. A. Naida, О. A. Zubchenko
doaj +1 more source
Perceptual and electrophysiological masking of the auditory brainstem response : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in Psychology at Massey University [PDF]
, 1987 Effective masking levels of the auditory brainstem response (ABR) to tonepips were established on 10 normal-hearing subjects at 500, 1000, 2000 and 4000 Hz, using white noise.
Houghton, Janene M
core
Adaptation by normal listeners to upward spectral shifts of speech: Implications for cochlear implants [PDF]
, 1999 Multi-channel cochlear implants typically present spectral information to the wrong ''place'' in the auditory nerve array, because electrodes can only be inserted partway into the cochlea.
Faulkner, A, Rosen, S, Wilkinson, L
core +1 more source
Hematopoietic (stem) cells—The elixir of life?
FEBS Letters, EarlyView.The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo +4 more
wiley +1 more source
The Influence of Outer Hair Cells on Tectorial Membrane Waves [PDF]
International Journal of BiomedicineThe cochlea, a vital structure for hearing, comprising the scala media, scala tympani, and scala vestibuli, separated by Reissner’s and basilar membranes.
Haruki Mizuno, Toshiaki Kitamura
doaj +1 more source
Nonlinear cochlear mechanics without direct vibration-amplification feedback
Physical Review Research, 2020 Recent in vivo recordings from the mammalian cochlea indicate that although the motion of the basilar membrane appears actively amplified and nonlinear only at frequencies relatively close to the peak of the response, the internal motions of the organ of
Alessandro Altoè, Christopher A. Shera
doaj +1 more source
Perceptual adaptation by normally hearing listeners to a simulated "hole" in hearing [PDF]
, 2006 Simulations of cochlear implants have demonstrated that the deleterious effects of a frequency misalignment between analysis bands and characteristic frequencies at basally shifted simulated electrode locations are significantly reduced with training ...
Andrew Faulkner +5 more
core +1 more source