Results 1 to 10 of about 31,425,090 (332)

Regularities of changing the dimensions of the main bore of the cylinder of TMZ-450D diesel engine during the technological process

Записки Горного института, 2021
The article deals with the problems arising during the mechanical and thermal treatment of the TMZ-450D diesel engine cylinder, which is the base part of the engines of small-sized generators and compressors, which are widely used for mobile units in the
Alexander S. Yamnikov, Lyudmila L. Safarova   +1 more
doaj   +1 more source

Wuzi Yanzong Pill relieves CPZ-induced demyelination by improving the microenvironment in the brain

Heliyon, 2022
Ethnopharmacology relevance: Wuzi Yanzong Pill (WYP), a well-known prescription for invigorating the kidney and essence, which is widely used to treat infertility such as oligoasthenospermia.
Yan-Rong Li, Meng-Ying Sun, Wei Hang, Qi Xiao, Hui-Jie Fan, Lu Jia, Xiao-Ming Jin, Bo Zhang, Bao-Guo Xiao, Cun-Gen Ma, Zhi Chai   +10 more
doaj   +1 more source

GSK3β-dependent lysosome biogenesis: An effective pathway to mitigate renal fibrosis with LM49

Frontiers in Pharmacology, 2022
Renal fibrosis is an incurable disorder characterised by an imbalance of the extracellular matrix (ECM) favouring excess production over degradation.
Jinhong Ren, Jinhong Ren, Huizhi Wei, Jian Sun, Xiue Feng, Yuanlin Zhang, Hongxia Yuan, Junqiu Miao, Xiaoming Qi, Xiaoming Qi, Yuanbiao Qiao, Baoguo Xiao, Qingshan Li, Qingshan Li   +13 more
doaj   +1 more source

5,2′-Dibromo-2,4′,5′-trihydroxydiphenylmethanone Inhibits LPS-Induced Vascular Inflammation by Targeting the Cav1 Protein

Molecules, 2022
Vascular inflammation is directly responsible for atherosclerosis. 5,2′-Dibromo-2,4′,5′-trihydroxydiphenylmethanone (TDD), a synthetic bromophenol derivative, exhibits anti-atherosclerosis and anti-inflammatory effects.
Hongxia Yuan, Qianyi Hou, Xiue Feng, Yuanlin Zhang, Fan Yang, Rui Ge, Qingshan Li   +6 more
doaj   +1 more source

Farrerol Inhibits Vascular Smooth Muscle Cell Proliferation and Protects Them From Oxidative Injury via Bidirectional Modulation of the PI3K/Akt/mTOR Signaling Pathway

Natural Product Communications, 2023
The inhibition of intimal hyperplasia (IH) is an effective strategy to improve the long-term outcome of endovascular therapy and prevent restenosis. Farrerol, a naturally occurring dihydroflavone with a variety of bioactivities, exerts inhibitory effects
Jiacheng Fang, Huanhuan Jiang, Enli Liu, Rui Ge, Qingshan Li   +4 more
doaj   +1 more source

Preventing development of post-stroke hyperexcitability by optogenetic or pharmacological stimulation of cortical excitatory activity

Neurobiology of Disease, 2023
Stroke is the most common cause of acquired epilepsy, but treatment for preventing the development of post-stroke epilepsy is still unavailable. Since stroke results in neuronal damage and death as well as initial loss of activity in the affected brain ...
Yadav Adhikari, Cun-Gen Ma, Zhi Chai, Xiaoming Jin   +3 more
doaj   +1 more source

Overregulation of Health Care: Musings on Disruptive Innovation Theory [PDF]

, 2006
Disruptive innovation theory provides one lens through which to describe how regulations may stifle innovation and increase costs. Basing their discussion on this theory, Curtis and Schulman consider some of the effects that regulatory controls may have ...
Dahlqvist Leinhard, Olof, Leijon, Göran, Lundberg, Peter, Lundin, Fredrik, Tisell, Anders, Tullberg, M., Wikkelso, C.   +6 more
core   +6 more sources

Antinociceptive Action of 4-(5′-Dimethylamino)-Naphthalenesulfonyl-2(3H)-Benzoxazolone (W3D) on Animal Models of Pain via Inhibitory Effects on NO and iNOS

Natural Product Communications, 2023
The new synthetic anti-inflammatory agent, 4-(5′-dimethylamino)-naphthalenesulfonyl-2(3H)-benzoxazolone (W3D), has demonstrated definite biological activity both in vitro and in vivo.
Sha Meng, Zhen Cao, Huiying Bai, Rui Ge, Shurong Ban, Li Tang, Qing-shan Li   +6 more
doaj   +1 more source

The Chemical Constituents of Diaphragma Juglandis Fructus and Their Inhibitory Effect on α-Glucosidase Activity

Molecules, 2022
In our current investigation, 37 constituents (1–37), including 11 megastigmanes (1–11), 17 flavonoids (12–28) and 9 phenylpropanoids (29–37), were isolated from a 70%-EtOH extract of Diaphragma juglandis Fructus.
Jinyan Tan, Yangang Cheng, Shihui Wang, Jianli Li, Haiqin Ren, Yuanbiao Qiao, Qingshan Li, Yingli Wang   +7 more
doaj   +1 more source

The many ways of the basing relation [PDF]

, 2019
A subject S's belief that Q is well-grounded if and only if it is based on a reason of S that gives S propositional justification for Q. Depending on the nature of S's reason, the process whereby S bases her belief that Q on it can vary. If S's reason is
Moretti, Luca, Piazza, Tommaso
core   +1 more source