Results 121 to 130 of about 34,952,696 (369)

Circulating histones as clinical biomarkers in critically ill conditions

open access: yesFEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez   +17 more
wiley   +1 more source

EVALUATION OF LIQUEFACTION POTENTIAL FOR LOOSE MINEFILL SLOPES

open access: yesTASK Quarterly, 2000
Uncompacted embankments of certain fine sands exhibit a spontaneous liquefaction potential, which cannot be evaluated basing on undrained shear strength alone.
PETER KUDELLA
doaj  

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

open access: yesFEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao   +7 more
wiley   +1 more source

BIOGEOGRAPHICAL REGIONALISATION BASING ON POTENTIAL VEGETATION. CASE STUDY: BISTRITA-NĂSĂUD COUNTY [PDF]

open access: yesAnalele Universităţii din Oradea: Seria Geografie, 2013
The County of Bistrita-Năsăud lies in north-central Romania, at the border between the Transylvanian Plateau and the Eastern Carpathians. Its geomorphology features mountains and hills, laid out in a south and westward widely opened natural ...
Ioan BÂCA   +3 more
doaj  

Future Astronomical Observatories on the Moon [PDF]

open access: yes
Papers at a workshop which consider the topic astronomical observations from a lunar base are presented. In part 1, the rationale for performing astronomy on the Moon is established and economic factors are considered.
Burns, Jack O., Mendell, Wendell W.
core   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

open access: yesFEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

open access: yesFEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi   +5 more
wiley   +1 more source

Flow‐based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product

open access: yesMolecular Oncology, EarlyView.
The number of circulating tumor cells obtained from prostate cancer patients was increased approximately 5‐fold compared to regular CellSearch when processing 2 mL diagnostic leukapheresis material aliquots and increased by 44‐fold when processing 20 mL DLA aliquots using the flow enrichment target capture Halbach‐array.
Michiel Stevens   +8 more
wiley   +1 more source

Astragaloside IV prevents enterovirus 71-induced pyroptosis through the TCF12-TXNIP-Keap1/Nrf2 axis

open access: yesJournal of Functional Foods
This study aimed to investigate the inhibitory effect of astragaloside IV (AS-IV) on enterovirus 71 (EV71)-induced pyroptosis. The results indicated that AST-IV inhibited EV71-induced pyroptosis in normal human gastric epithelial (GES-1) cells. Therefore,
JinFang Hao   +6 more
doaj  

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