Results 141 to 150 of about 76,251 (310)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Narrative based medicine: Narrative based medicine in an evidence based world
BMJ, 1999 This is the last in a series of five articles on narrative based medicine In a widely quoted riposte to critics who accused them of naive empiricism, Sackett and colleagues claimed that “the practice of evidence based medicine means integrating individual clinical expertise with the best available external clinical evidence By individual clinical ...
openaire +4 more sources
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Mechanical/structural design implications of space-basing on shuttle system
, 1971 A conceptual design study was conducted to identify some of the mechanical/structural differences which result from the use of a tug/payload combination in a space-basing mode as contrasted with a ground-based mode of operation.
Ludlow, K. G.
core
Targeting the Tumor Microbiota in Cancer Therapy Basing on Nanomaterials
ExplorationIntra‐tumoral microbiota, which is a potential component of the tumor microenvironment (TME), has been emerging as a key participant and driving factor in cancer.
Yanan Niu +4 more
doaj +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Basing Point Pricing: Competition versus Collusion.
The authors consider the implications of game-theoretic models for the competitive or collusive nature of basing point pricing. In one-shot games, equilibrium price schedules do not generally conform to basing point pricing with unrestricted price ...
Thisse, Jacques-Francois, Vives, Xavier
core
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
QUALITY OF LABOR RESOURCES IN RUSSIA: REGIONAL ASPECT
Russian Journal of Economics and Law, 2012 The article reveals the issues of labor resources formation, their quality characteristics in Russia and in the definite region - Vovlogda region. Basing on the dara of prediction estimations, the authors show that inmedium-term prospective we can see ...
A. A. Shabunova, G. V. Leonidova
doaj
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source