Results 121 to 130 of about 76,251 (310)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Beliefs, grounds, and the basing relation

open access: yes, 1996
A number of epistemologists have held that a person who has a particular a posteriori belief is justified in that belief only if it is based on adequate grounds.
Radcliffe, Dana Montford
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

The MX Basing Debate: The Reagan Plan and Alternatives [PDF]

open access: yes, 1981
This report discusses the Reagan MX basing plan, and the FY82 Defense authorization ...
Medalia, Jonathan
core  

Book Review: The Basing-Point System

open access: yes, 1949
The Supreme Court of the United States in deciding Federal Trade Commission v. The Cement Institute, et al. found that the pricing system utilized in the cement industry was unlawful.
Bowman, Ward S., Jr.
core   +3 more sources

EVALUATION OF LIQUEFACTION POTENTIAL FOR LOOSE MINEFILL SLOPES

open access: yesTASK Quarterly, 2000
Uncompacted embankments of certain fine sands exhibit a spontaneous liquefaction potential, which cannot be evaluated basing on undrained shear strength alone.
PETER KUDELLA
doaj  

Market appeal intelligently evaluation basing on integral monitoring functions using [PDF]

open access: yesMarketing i Menedžment Innovacij, 2014
The aim of the article. The aim of the article is to create guidelines for establising a mechanism for monitoring the commercial potential of intellectual property in industry. The author develops recommendations for its effective using.
A.P. Kosenko
doaj  

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Causation and the Epistemic Basing Relation

open access: yes, 2008
The epistemic-basing relation is the relation that holds between a reason, or one’s grounds, and one’s belief when the belief is held for that reason. As I will explain, understanding this relation is crucial for epistemology since basing a belief on a ...
Madison, Brent J C
core  

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