Results 151 to 160 of about 8,304,922 (298)

A Statistical Concept for Conditional Marketing Authorisation Based on the Intermediate and Final Outcomes of a Single Confirmatory Randomised Clinical Trial. [PDF]

Pharm Stat
Liu X, Thomas NH, Asikanius E, Pothet C, Großhennig A, Koch A.   +5 more
europepmc   +1 more source

Ligand-Based CoMFA Study on Pyridylpyrazolopyridine Derivatives as PKCθ Kinase Inhibitors [PDF]

, 2014
Pavithra K. Balasubramanian, Anand Balupuri, Seung Joo Cho   +2 more
openalex   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Universal methylprednisolone pulses for the induction therapy of lupus nephritis: why not? [PDF]

Lupus Sci Med
Ruiz-Irastorza G.
europepmc   +1 more source

HydroPML: Towards Unified Scientific Paradigms for Machine Learning and Process-based Hydrology

Qingsong Xu, Yilei Shi, Jonathan Bamber, Ye Tuo, Ralf Ludwig, Xiao Xiang Zhu   +5 more
openalex   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Prediction of UGT-mediated phase II metabolism via ligand- and structure-based predictive models. [PDF]

J Cheminform
Bono L, Lunghini F, Sabato E, Biswas AD, Mazzolari A, Pedretti A, Beccari AR, Vistoli G, Vittorio S.   +8 more
europepmc   +1 more source

Chalcone Scaffold based Antimycobacterial Agents

, 2014
Fliur Macaev
openalex   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Validation of the predictive value of combined prealbumin and lymphocyte score for prognosis of stage II/III gastric cancer following curative resection. [PDF]

Front Oncol
Peng W, Tan Y, Cheng J, Wu Z, Ou S, Luo J, Xiao H.   +6 more
europepmc   +1 more source