Results 41 to 50 of about 35,285,454 (346)

The dual nature of TDC – bridging dendritic and T cells in immunity

FEBS Letters, EarlyView.
TDC are hematopoietic cells combining dendritic and T cell features. They reach secondary lymphoid organs (SLOs) and peripheral organs (liver and lungs) after FLT3‐dependent development in the bone marrow and maturation in the thymus. TDC are activated and enriched in SLOs upon viral infection, suggesting that they might play unique immune roles, since
Maria Nelli, Mirela Kuka
wiley   +1 more source

Leveraging current insights on IL‐10‐producing dendritic cells for developing effective immunotherapeutic approaches

FEBS Letters, EarlyView.
In vivo IL‐10 produced by tissue‐resident tolDC is involved in maintaining/inducing tolerance. Depending on the agent used for ex vivo tolDC generation, cells acquire common features but prime T cells towards anergy, FOXP3+ Tregs, or Tr1 cells according to the levels of IL‐10 produced. Ex vivo‐induced tolDC were administered to patients to re‐establish/
Konstantina Morali, Gloria Giacomello, Michela Vuono, Silvia Gregori   +3 more
wiley   +1 more source

FoxO1 signaling in B cell malignancies and its therapeutic targeting

FEBS Letters, EarlyView.
FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac, Petra Pavelkova, Laura Ondrisova, Marek Mraz   +3 more
wiley   +1 more source

Global, regional, and national burden of chronic kidney disease attributable to high fasting plasma glucose from 1990 to 2019: a systematic analysis from the global burden of disease study 2019

Frontiers in Endocrinology
PurposeGiven the rising prevalence of high fasting plasma glucose (HFPG) over the past three decades, it is crucial to assess its global, national, and regional impact on chronic kidney disease (CKD).
Huizhi Wei, Jinhong Ren, Rui Li, Xiaoming Qi, Fan Yang, Qingshan Li, Qingshan Li   +6 more
doaj   +1 more source

Color Glass Condensate at the LHC: hadron multiplicities in $pp$, $pA$ and $AA$ collisions

, 2004
We make quantitative predictions for the rapidity and centrality dependencies of hadron multiplicities in $AA$, $pA$ and $pp$ collisions at the LHC energies basing on the ideas of parton saturation in the Color Glass Condensate.Comment: 26 pages, 8 ...
Adcox, Adcox, Adler, Armesto, Arsene, Back, Back, Back, Back, Back, Back, Back, Baker, Balitsky, Balitsky, Barnby, Bartels, Bartels, Bartels, Bazilevsky, Bazilevsky, Bearden, Bearden, Bearden, Bialas, Blaizot, Bondarenko, Braun, Braun, Brodsky, De Jager, De Jager, Debbe, Dmitri Kharzeev, Eidelman, Eskola, Eugene Levin, Golec-Biernat, Golec-Biernat, Gotsman, Gribov, Gyulassy, Hirano, Iancu, Iancu, Iancu, Iancu, Iancu, Iancu, Iancu, Iancu, Jalilian-Marian, Jalilian-Marian, Jalilian-Marian, Kharzeev, Kharzeev, Kharzeev, Kharzeev, Kharzeev, Kharzeev, Kharzeev, Khoze, Kovchegov, Kovchegov, Kovchegov, Kovchegov, Kovchegov, Kovchegov, Kozlov, Krasnitz, Kuraev, Laenen, Levin, Levin, Levin, Levin, Levin, Marzia Nardi, Matveev, McLerran, McLerran, McLerran, Milov, Mueller, Mueller, Mueller, Mueller, Mueller, Mueller, Munier, Nouicer, Stasto, Szczurek, Szczurek, Szczurek, Triantafyllopoulos, Weigert, Xu   +97 more
core   +1 more source

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

FEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi, WanTing Kong, Camille Blériot, Joel T. Haas   +3 more
wiley   +1 more source

MORPHOLOGICAL BASING SELECTION SEAMING MATERIAL BY OPERATION ON DUODENUM

Креативная хирургия и онкология, 2017
In surgical practice, with operations in the  duodenum using different types  of suture material. The experiment used 4 types of suture  material: Vikryl, polidiaksonon, kapron and silk.
R. R. Nuriakhmetov, I. Z. Salimgareev
doaj   +1 more source

Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley   +1 more source

Evaluation of the Fourth Millennium Development Goal Realisation Using Robust and Nonparametric Tools Offered by Data Depth Concept [PDF]

, 2015
We briefly communicate results of a nonparametric and robust evaluation of effects of \emph{the Fourth Millennium Development Goal of United Nations}.
Kosiorowska, Ewa, Kosiorowski, Daniel, Zawadzki, Zygmunt   +2 more
core  

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

FEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung, Mikhail G. Dozmorov, SuJeong Song, Theingi Aung, Min Hee Park, Patricia J. Sime, Wook‐Jin Chae   +6 more
wiley   +1 more source