Results 181 to 190 of about 43,933 (259)

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Towards the tumor microenvironment scoring methods for immune checkpoint inhibitor response. [PDF]

NPJ Precis Oncol
Zhou Q, Kirshtein A, Shahriyari L.
europepmc   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Multi-modal dissection of cell-type specific TDP-43 pathology in the motor cortex. [PDF]

Nat Commun
Ruf WP, Kühlwein JK, Meier L, Brockmann SJ, LeeBae J, Sadri-Vakili G, Yilmazer-Hanke D, Petri S, Thal DR, Grozdanov V, Danzer KM.   +10 more
europepmc   +1 more source

Highlighting Recent Progress in Fiber Energy Harvesters: From Working Principles to Future Perspectives

Advanced Science, EarlyView.
Fiber energy harvesters offer unprecedented flexibility and a unique capacity for integration into commercial textiles, overcoming the limitations of bulky and rigid conventional devices. This review summarizes recent advances in fiber‐based energy harvesting and provides strategic outlooks to accelerate technological progress in the field. ABSTRACT As
Hanhwi Jang, Junseong Ahn, Yongrok Jeong, Sohee Jeon, Soon Hyoung Hwang, Min‐Wook Oh, Jun‐Ho Jeong, Inkyu Park, Yeon Sik Jung   +8 more
wiley   +1 more source

Detection for New Biomarkers of Tuberculosis Infection Activity Using Machine Learning Methods. [PDF]

Diseases
Starshinova AA, Sabirova A, Koroteeva O, Kudryavtsev I, Rubinstein A, Aquino A, Trulioff AS, Belyaeva E, Kulpina A, Sharipov RA, Tukfatullin RK, Nikolenko NY, Mikhalev A, Savchenko AA, Borisov A, Kudlay D.   +15 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Interpretable inflammation landscape of circulating immune cells. [PDF]

Nat Med
Jiménez-Gracia L, Maspero D, Aguilar-Fernández S, Craighero F, Boulougouri M, Ruiz M, Marchese D, Caratù G, Liñares-Blanco J, Berasategi M, Ramirez Flores RO, Sanzo-Machuca A, Corraliza AM, Tran HA, Normand R, Nestor J, Hong Y, Kole T, van der Velde P, Alleblas F, Pedretti F, Aterido A, Banchero M, Soriano G, Román E, van den Berge M, Salas A, Carrascosa JM, Fernández Nebro A, Domènech E, Cañete JD, Tornero J, Gisbert JP, Choy E, Girolomoni G, Siegmund B, Julià A, Serra V, Elosua R, Tejpar S, Vidal S, Nawijn MC, Gut I, Saez-Rodriguez J, Marsal S, Villani AC, Nieto JC, Heyn H.   +47 more
europepmc   +1 more source