Results 91 to 100 of about 7,515 (307)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Metaheuristics for Order Batching and Sequencing in Manual Order Picking Systems [PDF]
Order picking deals with the retrieval of articles from their storage locations in order to satisfy customer requests. A major issue in manual order picking systems concerns of the transformation and consolidation of customer orders into picking orders ...
Verena Schmid, Sebastian Henn
core
FEBS Open Bio, EarlyView.Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani +6 more
wiley +1 more source
Order batching in multi-server pick-and-sort warehouses. [PDF]
In many warehouses, customer orders are batched to profit from a reduction in the order picking effort. This reduction has to be offset against an increase in sorting effort.
Van Nieuwenhuyse, Inneke +2 more
core
Automatic concrete slump prediction of concrete batching plant by deep learning
Developments in the Built EnvironmentThe workability of fresh concrete is highly important in terms of construction quality and safety. Slump tests are required every 120 m³, yet automated monitoring for each concrete batch remains unavailable in the actual concrete batching plant.
Sarmad Idrees +6 more
doaj +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley +1 more source
Minimizing the sum of flow times with batching and delivery in a supply chain
, 2005 This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.The aim of this thesis is to study one of the classical scheduling objectives that is of minimizing the sum of flow times, in the context of a supply chain ...
Mazdeh, Mohammad Mahdavi +1 more
core
Stochastic Momentum Method With Double Acceleration for Regularized Empirical Risk Minimization
IEEE Access, 2019 Momentum acceleration technique is famously known for building gradient-based algorithms with fast convergence in large-scale optimization. Recently, Nesterov 's momentum and Katyusha momentum have significantly improved the convergence for stochastic ...
Zhijian Luo, Siyu Chen, Yuntao Qian
doaj +1 more source
Directed evolution of enzymes at the crossroads of tradition and innovation
FEBS Open Bio, EarlyView.An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova +2 more
wiley +1 more source