Results 71 to 80 of about 7,515 (307)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Batch Symmetric Fully Homomorphic Encryption Using Matrix Polynomials

open access: yesТруды Института системного программирования РАН, 2018
Fully homomorphic encryption (FHE) is a recognized tool to obtain the cryptographic protec-tion of cloud computing. However, the characteristics of existing FHE schemes are not suffi-cient for use in practice the security of some FHE is unsatisfying ...
Ph. Burtyka
doaj   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

open access: yesFEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui   +10 more
wiley   +1 more source

Algorithms for On-line Order Batching in an Order-Picking Warehouse [PDF]

open access: yes
In manual order picking systems, order pickers walk or ride through a distribution warehouse in order to collect items required by (internal or external) customers.
Sebastian Henn
core  

Design and analysis of online batching systems

open access: yes, 2006
In this paper, we study the design and analysis of online batching systems. In particular, we analyze the tradeoff relationship between the start-up delay and the efficient usage of resources in an online batching system, and analyze how the delay ...
Regant Y. S. Hung   +3 more
core   +1 more source

Accurate batching of concrete

open access: yesMateriales de Construccion, 1950
No ...
W.B. Lenhart
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

A Grouping Genetic Algorithm for the Order Batching Problem in Distribution Warehouses [PDF]

open access: yes
Order picking is a warehouse function that deals with the retrieval of articles from their storage locations in order to satisfy certain customer demands. Combining several single customer orders into one (more substantial) picking order can increase the
Sören Koch, Gerhard Wäscher
core  

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