Results 21 to 30 of about 543,173 (259)

Pilot Studies on Two Complementary Bath Products for Atopic Dermatitis Children: Pine-Tar and Tea

open access: yesMedicines, 2019
Background: Few standardized bath product clinical trials were performed for atopic dermatitis patients. Pine-tar and green tea extracts are plant-derived products that have been described as having anti-allergic effects which may reduce AD disease ...
Kam Lun Hon   +4 more
doaj   +1 more source

Branding potential of spas in the Northern Plain and the Mid-Transdanubian Regions

open access: yesApstract: Applied Studies in Agribusiness and Commerce, 2013
Based on both primary and secondary research in our article we examined the brand elements of the main baths of the NorthernPlain Region (Szolnok Liget Thermal and Experience Bath, Nyiregyháza Aquarius Experience Bath, a Hajdúszoboszló Hungarospa Plc ...
Attila Mosonyi   +2 more
doaj   +1 more source

Comparison of temporal fluctuations in the total electron content estimates from EISCAT and GPS along the same line of sight [PDF]

open access: yesAnnales Geophysicae, 2013
The impact of space weather events on satellite-based technologies (e.g. satellite navigation and precise positioning) is typically quantified on the basis of the total electron content (TEC) and temporal fluctuations associated with it.
B. Forte   +11 more
doaj   +1 more source

Exercise‐induced amplification of mitogen‐stimulated oxidative burst in whole blood is strongly influenced by neutrophil counts during and following exercise

open access: yesPhysiological Reports, 2021
This study characterized the effect of moderate‐ or vigorous‐intensity exercise on leukocyte counts, using fingertip sampling, and mitogen‐stimulated oxidative burst, measured in whole blood with a point‐of‐care test. In a randomized crossover design, 13
A. Lester   +6 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

Patient–clinician dynamics in remote consultations: a qualitative study of cardiology and rheumatology outpatient clinics in the UK

open access: yesBMJ Open, 2023
Objective Explore the experiences of patients and clinicians in rheumatology and cardiology outpatient clinics during the first year of the COVID-19 pandemic, focusing on the impact of remote consultations on interpersonal dynamics.Design Qualitative ...
Raj Sengupta   +7 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

open access: yesFEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji   +2 more
wiley   +1 more source

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

open access: yesFEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento   +6 more
wiley   +1 more source

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