Results 31 to 40 of about 203,854 (298)
Open Veterinary JournalBackground: Breast cancer affects women at various ages, and its recurrence is a significant cause of death. The search for potent anticancer compounds of herbal origin with well-defined mechanisms of action is an essential focus of current research ...
Wurlina Wurlina +13 more
doaj +1 more source
СТРУКТУРНЫЕ ДЕТЕРМИНАНТЫ ВЫТЕСНЕНИЯ БЕЛКА Bax ИЗ КОМПЛЕКСА TOM/Bax БЕЛКОМ tBid ПРИ АПОПТОЗЕ [PDF]
, 2018 Structural factors that induce the proapoptotic activation of Bax by the protein TOM22 of the TOM complex and BH3-only protein tBid are established.
Valery G. Veresov +5 more
core +1 more source
: the awakening of Bax and Bak pores [PDF]
, 2018 The mechanism whereby mitochondrial DNA (mtDNA) is released into the cytosol and activates the cGAS/STING inflammatory pathway during Bax/Bax‐mediated apoptosis is unknown.
Katia Cosentino +3 more
core +2 more sources
Mitochondrial Fusion: Bax to the Fussure [PDF]
Developmental Cell, 2011 Mitochondria can be organized into highly interconnected networks through continuous cycles of fission and fusion. A recent study by Hoppins et al. (2011) published in Molecular Cell now suggests that Bax, more commonly known for its role in apoptosis, can promote mitochondrial fusion in a Mitofusin 2-dependent manner.
openaire +3 more sources
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter [PDF]
, 2002 Although the promoters of both the Bax and p21 genes are activated by p53, they differ in the effect on this activation of the POU family transcription factor Brn-3a. Thus, Brn-3a inhibits activation of the Bax promoter by p53 but enhances the ability of
Budhram-Mahadeo, VS +2 more
core
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Solo show, Cavalcade, BoLee and Workman, Bruton
Cavalcade is a solo exhibition of new work by artist Olivia Bax. Situated in a former Methodist church, the sculptures respond to the space’s distinctive architecture.
BoLee and Workman, Bax, Olivia
core +3 more sources
Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes. [PDF]
, 2012 Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other ...
Alexander Y. Andreyev (132842) +11 more
core +1 more source
Malformin A1–mediated cytotoxicity in ovarian cancer cells occurs through pyroptosis and autophagy
FEBS Open Bio, EarlyView.This study investigated the effects of the natural compound Malformin A1 (MA1) on the cytoskeleton that regulates cell proliferation and migration. Disruption of the cytoskeleton can impair these processes and promote cancer cell death. MA1 disrupted cytoskeletal organization, induced DNA damage, inflammation, activated autophagy, and pyroptosis ...
Nada Abdullah Hassan +11 more
wiley +1 more source