Results 41 to 50 of about 203,854 (298)

Bax ablation rescues chondrocytes.

, 2012
Proliferative HCS chondrocytic cells treated with Dexa (25 µM) for 72 hrs were analyzed for the expression of the (A) Bax and (B) Bcl-2 proteins. (C) Bax ablation protected proliferative chondrocytes from Dexa-induced apoptosis.
Lars Sävendahl (114293), Farasat Zaman (114281), Kirsten Huntjens (177119), Bengt Fadeel (127548), Dionisios Chrysis (114283)   +4 more
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Application of cryo-electron microscopy for investigation of Bax-induced pores in apoptosis

Nanotechnology Reviews, 2017
Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis, the molecular mechanisms of which have been a subject of intensive study.
Kuwana Tomomi
doaj   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

Association of Bax expression and Bcl2/Bax ratio with clinical and molecular prognostic markers in chronic lymphocytic leukemia [PDF]

Journal of Medical Biochemistry, 2016
Background: In chronic lymphocytic leukemia (CLL), in vivo apoptotic resistance of malignant B lymphocytes results, in part, from the intrinsic defects of their apoptotic machinery.
Vučićević Ksenija, Jakovljević Vladimir, Čolović Nataša, Tošić Nataša, Kostić Tatjana, Glumac Irena, Pavlović Sonja, Karan-Đurašević Teodora, Čolović Milica   +8 more
doaj  

Estudo do efeito neuroprotetor da mirtazapina e imipramina e sua relação com a expressão gênica de proteínas apoptóticas [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências.Neste estudo foram investigados a ação neuroprotetora dos antidepressivos mirtazapina e imipramina e os efeitos ...
Lieberknecht, Vicente
core  

Bax and Bak were critical mediator of WithaD-mediated apoptosis.

, 2012
(A) Expression of p53, Bax, Bak and Cytochrome c were evaluated in the lysate of HCT116 cells proficient for Bax and Bak (Bax+/Bak+), deficient for either Bax (Bax−/Bak+) or Bak (Bax+/Bak−) or deficient for both Bax and Bak (Bax−/Bak−) after WithaD (0–2 ...
Kaushik Bhattacharya (148096), Chitra Mandal (148111), Asish Mallick (174653), Susmita Mondal (174649), Rajender Sangwan (174658)   +4 more
core   +1 more source

Mitochondrial targeting of the pro-apoptotic protein Bax : Role of the Bax carboxy-terminal tail. [PDF]

, 2009
Here, I address the function of the carboxy-terminal hydrophobic helix of the pro-apoptotic protein Bax. There has been considerable controversy as to whether this sequence is required for the targeting and insertion of Bax into the mitochondrial outer ...
Brock, Stephanie Erin, 1980-
core   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source