Results 71 to 80 of about 203,854 (298)

Analysis of the expressional level of Bim and Bax.

, 2014
A, representative western blotting images of Bim, Bax and cleaved caspase-3. B, statistics of the protein level of Bim; C, statistics of the protein level of Bax.
Yongxin Luan (560367), Yi-nan Luo (560368), Jianmin Liang (560366), Pengfei Ge (383450), Bin Lu (65603), Hongbo Zhang (427842)   +5 more
core   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

Effect of Lutein on Proliferation and Apoptosis of Human Prostate Cancer PC3 Cell Line and Related Mechanism

Zhongliu Fangzhi Yanjiu, 2018
Objective To investigate the mechanism of lutein on the proliferation and apoptosis of human prostate cancer PC3 cells, and to provide a new theoretical basis for the treatment and prevention of prostate cancer.
WANG Liping, FU Lei, YE Shuke, LIU Weihua, WANG Yale, WANG Mingchen   +5 more
doaj   +1 more source

Anti-apoptotic activity of α-crystallins against Bax-induced apoptosis.

, 2013
293T cells were transiently co-transfected with pcDNA3-Bax and with either the empty pcDNA3.1, pcDNA3.1-αA- (αA) or pcDNA3.1-αB (αB)-crystallin constructs.
Séverine Hamann (260988), Sandra Cottet (260989), Daniel F. Schorderet (49874), Sylviane Métrailler (285416)   +3 more
core   +1 more source

Upadacitinib Restrains the Pathogenic Fitness of CD4+ T Cells and Aberrant B Cell Programming in Optic Neuritis

Advanced Science, EarlyView.
Single‐cell profiling and functional perturbation reveal coordinated JAK1‐pSTAT3 downstream programs in optic neuritis, including MCL1‐dependent fitness of pathogenic CD4+ Tem cells and glycolysis‐linked, cholesterol‐sensitive B‐cell responses associated with RORA. Upadacitinib disrupts this reciprocal T‐B‐cell circuit and alleviates neuroinflammation,
Gengchen Jiang, Qi Jiang, Lian Han, Yue Peng, Xingyu Liu, Tong Yang, Hao Huang, Jiaying Liu, Yuan Gao, Hui Yang, Wenjun Zou, Zhaohuai Li, Wenru Su   +12 more
wiley   +1 more source

Active Bax and Bak are functional holins

, 2011
The mechanism of Bax/Bak-dependent mitochondrial outer membrane permeabilization (MOMP), a central apoptotic event primarily controlled by the Bcl-2 family proteins, remains not well understood.
Natalie M. Targy, Kenneth W. Bayles, Hernando Lopez, Liqiang Zhang, Ry Young, Nicholas M. George, Xu Luo, Casey Gries, Jeffrey L. Bose, Samir H. Moussa, Xiaming Pang   +10 more
core   +1 more source

Lactylation‐Driven PROS1‐TYRO3‐CARF Signaling Promotes Therapy‐Induced Senescence Escape and Radioresistance in Meningioma

Advanced Science, EarlyView.
A glycolysis‐driven epigenetic switch promotes therapy resistance in meningioma. Increased lactate production enhances histone H3K27 lactylation, which activates PROS1 secretion. Secreted PROS1 engages TYRO3 signaling to degrade the senescence regulator CARF, allowing cancer cells to escape growth arrest.
Zhuohang Wang, Qixiang Zhang, Keman Liao, Xiaoyu Liu, Hongchi Zhang, Yunsheng Chen, Yuxiao Ma, Yikui Liu, Aoqian Xu, Yuhao Sun, Jiayi Chen, Liuguan Bian, Baofeng Wang   +12 more
wiley   +1 more source

miR-346 Inhibited Apoptosis Against Myocardial Ischemia-Reperfusion Injury via Targeting Bax in Rats

Drug Design, Development and Therapy, 2020
Xiangwei Lv,1,* Pan Lu,1,* Yisen Hu,2 Tongtong Xu1 1Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Cardiology, First Affiliated
Lv X, Lu P, Hu Y, Xu T
doaj  

ROS/pH‐Responsive Phenylboronic Acid–Chitosan Nanoparticles Improve Silymarin‐Mediated Hepatoprotection After Hepatectomy With Gut‐Liver Axis‐Associated Responses

Advanced Science, EarlyView.
Bioactive phenylboronic acid–chitosan nanoparticles enable responsive silymarin delivery for post‐hepatectomy liver protection. The nanoplatform integrates antioxidant and antibacterial functions, improves hepatic recovery, and is associated with coordinated shifts in gut microbiota, metabolites, cytokines, and hepatic proteomic pathways, suggesting a ...
Jinjin Tong, Chaochao Luo, Zezheng Liu, Xinyan Zhang, Daixu Jia, Yang Sun, Zhaonan Zhang, Haoran Shi, Jianfang Wang, Hua Zhang   +9 more
wiley   +1 more source

E2F1 induces Bax activation, dimerization and translocation to the mitochondria.

, 2012
(A) PC12 ER-E2F1 cells were transiently transfected with an YFP-Bax plasmid, serum-deprived and treated with (OHT) or without (control) OHT for 3 hours. YFP-Bax localization was achieved by immunofluorescence as indicated in Material and Methods.
Nathalie Meo-Evoli (111381), Albert Tauler (111391), Lilia Espada (111380), Isabel Fabregat (106990), Santiago Ambrosio (111388), Sebastian Real (111385), Patricia Sancho (111383)   +6 more
core   +1 more source