Results 51 to 60 of about 240,583 (209)
Бюллетень сибирской медицины, 2005 The study aim: to investigate the dynamics of transcription factor p53, proapoptoic (bax, bcl-XS), antiapoptotic (bcl-2, bcl-XL) effectors, IL-5 expression in peripheral blood eosinophils of patients with severe therapy-resistant bronchial asthma (BA ...
L. Yu. Nikitina +3 more
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VDAC2 enables BAX to mediate apoptosis and limit tumor development
Nature Communications, 2018 Intrinsic apoptosis is critical to prevent tumor formation and is engaged by many anti-cancer agents to eliminate tumor cells. BAX and BAK, the two essential mediators of apoptosis, are thought to be regulated through similar mechanisms and act ...
H. S. Chin +26 more
semanticscholar +1 more source
BAX to basics: How the BCL2 gene family controls the death of retinal ganglion cells
Progress in retinal and eye research, 2017 Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve. For several decades, we have understood that the RGC death process was executed by apoptosis, suggesting that there may be ways to therapeutically intervene in ...
Margaret E. Maes +2 more
semanticscholar +1 more source
Cancer Management and Research, 2018 Purpose Many anticancer drugs induce apoptosis in malignant cells, and resistance to apoptosis could lead to suboptimal or no therapeutic benefit. Two cytoplasmic proteins, B-cell lymphoma protein 2 (Bcl-2)-associated X (Bax) and Bcl-2, act as a promoter
Bibi Kulsoom +5 more
semanticscholar +1 more source
The role of cardiolipin in promoting the membrane pore-forming activity of BAX oligomers.
Biochimica et Biophysica Acta - Biomembranes, 2019 BCL-2-associated X (BAX) protein acts as a gatekeeper in regulating mitochondria-dependent apoptosis. Under cellular stress, BAX becomes activated and transforms into a lethal oligomer that causes mitochondrial outer membrane permeabilization (MOMP ...
Yei-Chen Lai +5 more
semanticscholar +1 more source
Medical Laboratory Journal, 2019 Background and Objectives: Exercise is a strong physiological stimulus that can affect apoptosis in the lungs by altering a number of extracellular and intracellular signaling pathways.
somayeh ramezani +3 more
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Completion of BAX recruitment correlates with mitochondrial fission during apoptosis
Scientific Reports, 2019 BAX, a member of the BCL2 gene family, controls the committed step of the intrinsic apoptotic program. Mitochondrial fragmentation is a commonly observed feature of apoptosis, which occurs through the process of mitochondrial fission.
Margaret E. Maes +4 more
semanticscholar +1 more source
اثر تمرینات هوازی تداومی و تناوبی بر بیان ژنهای p53 و Bax و ارتباط آن با استرس اکسیداتیو و مرگ برنامهریزیشده سلولی در میوکارد رتهای مبتلا به انفارکتوس [PDF]
Majallah-i Dānishkadah-i Pizishkī-i Dānishgāh-i ̒ Ulūm-i Pizishkī-i Mashhad.مقدمه: آنفارکتوس میوکارد (MI) یکی از عوامل اصلی مرگومیر قلبیعروقی در جهان است که باعث ایجاد استرس اکسیداتیو و مرگ برنامهریزیشده سلولی در بافت قلب میشود. این مطالعه تأثیر تمرینات هوازی تداومی (MICT) و تناوبی با شدت بالا (HIIT) را بر بیان ژنهای p53 و
بهاره مردانی +3 more
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Release of Cytochrome C from Bax Pores at the Mitochondrial Membrane
Scientific Reports, 2017 How cytochrome C is released from the mitochondria to the cytosol via Bax oligomeric pores, a process which is required for apoptosis, is still a mystery.
Mingzhen Zhang +3 more
semanticscholar +1 more source
miR-346 Inhibited Apoptosis Against Myocardial Ischemia-Reperfusion Injury via Targeting Bax in Rats
Drug Design, Development and Therapy, 2020 Xiangwei Lv,1,* Pan Lu,1,* Yisen Hu,2 Tongtong Xu1 1Department of Cardiology, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, People’s Republic of China; 2Department of Cardiology, First Affiliated
Lv X, Lu P, Hu Y, Xu T
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