Results 161 to 170 of about 320,112 (306)

Evaluating the Protective Effect of Melatonin on Apoptosis, Expression of Bax and Bcl2 Genes, and ROS Level after Radiofrequency Radiation on L929 Fibroblast Cell Line. [PDF]

J Biomed Phys Eng
Fardid R, Zaker F, Haghani M, Saberzadeh J.   +3 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Chrysoeriol-Mediated Neuroprotection in Parkinson's Disease in Mice: Targeting Apoptosis, α-Synuclein Accumulation, and Functional Recovery. [PDF]

Yale J Biol Med
Ali M, Mehreen M, Batool S, Khan S, Noor A, Mumtaz S, Zafar S.   +6 more
europepmc   +1 more source

Targeting eIF5A combats breast cancer progression by ClpP‐dependent mitochondrial oxidative stress

Interdisciplinary Medicine, EarlyView.
This study identified the eIF5A‐ClpP axis as a key driver of breast cancer progression. Targeting eIF5A suppresses tumor growth by inducing ClpP‐dependent mitochondrial oxidative stress, revealing a novel therapeutic vulnerability. Abstract Breast cancer (BC) poses a persistent global health challenge, necessitating new therapeutic targets.
Jinmei Zhu, Baoyuan Tang, Bei Xie, Haohua Deng, Haitang Yang, Lei Ma, Ziqing Zhang, Yicheng Ma, Xingyuan Ma, Shuaiyang Wang, Jing Li, Lei Zhao, Wengui Shi, Linjing Li   +13 more
wiley   +1 more source

Structure of Bax [PDF]

Cell, 2000
Suzuki, Motoshi, Youle, Richard J., Tjandra, Nico   +2 more
openaire   +1 more source

In Silico and In Vitro Investigation of Apoptosis-Mediated Antiproliferative Activity of Capsaicin and Alpha-Lipoic Acid Against Prostate Cancer Cells. [PDF]

Curr Issues Mol Biol
Meral O, Balkan BM, Bestil DN, Sayiner S, Ceylanli D, Uyurca S, Pehlivan S, Ozkurt G, Kismali G, Sel T.   +9 more
europepmc   +1 more source

Revisiting EWMA in High‐Frequency‐Based Portfolio Optimization: A Comparative Assessment

Journal of Applied Econometrics, EarlyView.
ABSTRACT This paper compares the statistical and economic performance of state‐of‐the‐art high‐frequency (HF) based multivariate volatility models with a simpler, widely used alternative, the Exponentially Weighted Moving Average (EWMA) filter. Using over two decades of 100 U.S.
Laura Capera Romero, Anne Opschoor
wiley   +1 more source

Avoiding Mitochondrial Apoptosis by the Bcl-2-Driven Bax Oligomerization on Membrane Surfaces. [PDF]

ACS Chem Biol
Ayscough SE, Clifton LA, Ådén J, Köhler S, Paracini N, Doutch J, Bragginton ÉC, Leung AE, Bogojevic O, Poon JF, Nagy TM, Wacklin-Knecht HP, Gröbner G.   +12 more
europepmc   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

A gated hydrophobic funnel within BAX binds bioactive lipids to potentiate pro-apoptotic function. [PDF]

Nat Commun
Gelles JD, Chen Y, Luna-Vargas MPA, Viacava Follis A, Al Noman MA, Kabir M, Bayiokos SG, Mohammed JN, Sebastian TM, Pham ND, Shi Y, Jin J, Kriwacki RW, Chipuk JE.   +13 more
europepmc   +1 more source