Results 41 to 50 of about 202,367 (202)
: the awakening of Bax and Bak pores [PDF]
, 2018 The mechanism whereby mitochondrial DNA (mtDNA) is released into the cytosol and activates the cGAS/STING inflammatory pathway during Bax/Bax‐mediated apoptosis is unknown.
Katia Cosentino +3 more
core +2 more sources
СТРУКТУРНЫЕ ДЕТЕРМИНАНТЫ ВЫТЕСНЕНИЯ БЕЛКА Bax ИЗ КОМПЛЕКСА TOM/Bax БЕЛКОМ tBid ПРИ АПОПТОЗЕ [PDF]
, 2018 Structural factors that induce the proapoptotic activation of Bax by the protein TOM22 of the TOM complex and BH3-only protein tBid are established.
Valery G. Veresov +5 more
core +1 more source
Mitochondrial Fusion: Bax to the Fussure [PDF]
Developmental Cell, 2011 Mitochondria can be organized into highly interconnected networks through continuous cycles of fission and fusion. A recent study by Hoppins et al. (2011) published in Molecular Cell now suggests that Bax, more commonly known for its role in apoptosis, can promote mitochondrial fusion in a Mitofusin 2-dependent manner.
openaire +3 more sources
Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter [PDF]
, 2002 Although the promoters of both the Bax and p21 genes are activated by p53, they differ in the effect on this activation of the POU family transcription factor Brn-3a. Thus, Brn-3a inhibits activation of the Bax promoter by p53 but enhances the ability of
Budhram-Mahadeo, VS +2 more
core
Bax activation initiates the assembly of a multimeric catalyst that facilitates Bax pore formation in mitochondrial outer membranes. [PDF]
, 2012 Bax/Bak-mediated mitochondrial outer membrane permeabilization (MOMP) is essential for "intrinsic" apoptotic cell death. Published studies used synthetic liposomes to reveal an intrinsic pore-forming activity of Bax, but it is unclear how other ...
Alexander Y. Andreyev (132842) +11 more
core +1 more source
Zhongliu Fangzhi Yanjiu, 2018 Objective To investigate the mechanism of lutein on the proliferation and apoptosis of human prostate cancer PC3 cells, and to provide a new theoretical basis for the treatment and prevention of prostate cancer.
WANG Liping +5 more
doaj +1 more source
Bax ablation rescues chondrocytes.
, 2012 Proliferative HCS chondrocytic cells treated with Dexa (25 µM) for 72 hrs were analyzed for the expression of the (A) Bax and (B) Bcl-2 proteins. (C) Bax ablation protected proliferative chondrocytes from Dexa-induced apoptosis.
Lars Sävendahl (114293) +4 more
core +1 more source
Application of cryo-electron microscopy for investigation of Bax-induced pores in apoptosis
Nanotechnology Reviews, 2017 Mitochondrial outer membrane permeabilization (MOMP) is a critical step in apoptosis, the molecular mechanisms of which have been a subject of intensive study.
Kuwana Tomomi
doaj +1 more source
Bax and Bak were critical mediator of WithaD-mediated apoptosis.
, 2012 (A) Expression of p53, Bax, Bak and Cytochrome c were evaluated in the lysate of HCT116 cells proficient for Bax and Bak (Bax+/Bak+), deficient for either Bax (Bax−/Bak+) or Bak (Bax+/Bak−) or deficient for both Bax and Bak (Bax−/Bak−) after WithaD (0–2 ...
Kaushik Bhattacharya (148096) +4 more
core +1 more source