Results 71 to 80 of about 202,367 (202)

The substitution of Proline 168 favors Bax oligomerization and stimulates its interaction with LUVs and mitochondria

, 2017
International audienceBax is a major player in the apoptotic process, being at the core of the mitochondria permeabilization events. In spite of the major recent advances in the knowledge of Bax organization within the membrane, the precise behavior of ...
Durand, Grégory, Gonzalez, Cécile, Lascu, Ioan, Giraud, Marie-France, Grégory Durand, Manon, Stéphen, Alexandre Légiot, Légiot, Alexandre, Simonyan, Lilit, Ioan Lascu, Cécile Gonzalez, Stéphen Manon, Marie-France Giraud, Lilit Simonyan   +13 more
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Completion of BAX recruitment correlates with mitochondrial fission during apoptosis [PDF]

, 2019
BAX, a member of the BCL2 gene family, controls the committed step of the intrinsic apoptotic program. Mitochondrial fragmentation is a commonly observed feature of apoptosis, which occurs through the process of mitochondrial fission.
Maes, Margaret E ; https://orcid.org/, Grosser, J. A., Fehrman, R. L., Nickells, R. W., Schlamp, C. L.   +4 more
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Effect of Ascorbic Acid on Signaling Pathways of Bcl2 and Bax Genes in AGS Cell Line

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Īlām, 2020
Introduction: Antioxidants have a great influence on the control of oxidative stress and free radicals; moreover, they cause the expression of apoptosis genes. Accordingly, they have an important role in preventing cancer.
yaser Asefi, Saeid Ghorbian
doaj  

BAX Can Be Allosterically Sensitized to Promote Apoptosis

, 2017
An NMR-based fragment screen identified a BAX-interacting compound, BIF-44, that enhances BAX activity.

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Effect of 8 Weeks High Intensity Interval Training on the Gene Expression of BAX and BCL-2 in the Left Ventricle of Diabetic Male Wistar Rats

Majallah-i Dānishgāh-i ’Ulūm-i Pizishkī-i Shahīd Ṣadūqī Yazd, 2020
Introduction: Regular exercise training with alternating volume fluctuatesblood glucous levels and by regulating signaling in gene expression reduces in myocardial cell apoptosis in diabetic patients.
Alireza Safarnezhad, Maghsoud Peeri, Mohammad Ali Azarbayjani, Maryam Delfan   +3 more
doaj  

Effect of the Adiantum capillus Veneris Extract on Bax and Bcl2 Apoptotic Markers of Lung Modulation in Trained Rats and Exposed to Hypoxic Stress

Journal of Medicinal Plants, 2017
Background: Apoptosis is a type of programmed cell death that occurs by a series of Intercellular messages under Specific conditions. Objective: The aim of present study was investigat role of the Adiantum capillus veneris extract on modulation of Bax ...
M Yadegari, S Riahy, Sh Mirdar, GhR Hamidian, P Mosadegh zavaragh   +4 more
doaj  

Allosteric Sensitization of Pro-Apoptotic BAX

, 2018
BAX is a critical apoptotic regulator that can be transformed from a cytosolic monomer into a lethal mitochondrial oligomer, yet drug strategies to modulate it are underdeveloped due to longstanding difficulties in conducting screens on this aggregation ...
Wales, Thomas E., Cohen, Daniel, Engen, John R., Luccarelli, James, Wachter, Franziska, Lee, Susan, Heffron, Gregory, Coote, Paul, Pritz, Jonathan R., Massefski, Walter, Walensky, Loren   +10 more
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Effects of concurrent regular aerobic training and garlic extract on cardiac tissue apoptosis markers in aged rats with chronic kidney disease

Journal of Medicinal Plants, 2017
Background: One of the problems due to aging is apoptosis development in various tissues of body. There is some evidence that some drugs induce apoptosis development via oxidative stress.
Zeynab Razavi Majd, Hassan Matin Homaee, Mohammad Ali Azarbayjani, Parvin Farzanegi   +3 more
doaj  

The C-terminal extension domain of αA-crystallin was sufficient to provide protection against Bax-induced apoptosis.

, 2013
Twenty-four hours post-transfection, 293T cells transfected with Bax (Bax/pRluc) or with Bax and αA-crystallin wt or mutants were assayed in TUNEL assay.
Séverine Hamann (260988), Sandra Cottet (260989), Daniel F. Schorderet (49874), Sylviane Métrailler (285416)   +3 more
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Metformin alters signaling induced crosstalk and homeostasis in the carcinogenesis paradigm “Epistemology of the origin of cancer”

4 open, 2019
The anti-hyperglycemic drug, Metformin, is effective in treating early stages of diabetes and has been associated with a 37% decrease in cancer incidence. While the precise mechanisms for the anti-cancer effects of Metformin remain to be elucidated, this
Brücher Björn L.D.M., Jamall Ijaz S.
doaj   +1 more source