Results 151 to 160 of about 235,115 (280)

Cellular Identity Crisis: RD3 Loss Fuels Plasticity and Immune Silence in Progressive Neuroblastoma

Advanced Science, EarlyView.
Researchers discovered that therapy‐induced loss of RD3 protein in neuroblastoma triggers a dangerous shift: cancer cells become more stem‐like, invasive, and resistant to treatment while evading immune detection. RD3 loss suppresses antigen presentation and boosts immune checkpoints, creating an immune‐silent environment.
Poorvi Subramanian, Sreenidhi Mohanvelu, Sheeja Aravindan, Afsana Parveen Jahir Hussain, Sivasubramani Narayanan, Sabir Salim, Loganayaki Periyasamy, Natarajan Aravindan   +7 more
wiley   +1 more source

Global expert consensus on the importance of secondary stroke prevention: challenges, care coordination and unmet needs for non-cardioembolic ischaemic stroke survivors. [PDF]

Eur Stroke J
Caso V, Agredano J, Cordonnier C, Dawson J, De Marchis GM, Haeusler KG, Hirano T, Liu L, Masjuan J, Nikolić N, Proios H, Siger A, Tangen MH, Wilkie A.   +13 more
europepmc   +1 more source

Natural Variations of ZmRLR1 Mediate the Root Lodging Resistance of Maize by Regulating Root Ascorbate and Auxin Homeostasis

Advanced Science, EarlyView.
Root lodging severely limits crop yield and quality. We reveal that ZmRLR1, a plasma membrane b‐type cytochrome, regulates lodging resistance in maize through dual roles: modulating intracellular redox balance and functioning as a novel component of clathrin‐mediated endocytosis to influence auxin homeostasis. Moreover, natural variations in the ZmRLR1
Wenshuai Lv, Pengshuai Yan, Huan Chen, Guangxian Li, Yiyue Zhao, Yanhui Chen, Wen‐Xue Li, Qingguo Du   +7 more
wiley   +1 more source

Safety and Efficacy of Damoctocog Alfa Pegol in Previously Treated Children Aged 7 to < 12 Years With Severe Haemophilia A in the Phase 3, Open Label Alfa-PROTECT Main Study. [PDF]

Eur J Haematol
Ozelo MC, Luciani M, Glosli H, Kavakli K, Samji N, Makris GC, Tueckmantel C, Maas Enriquez M, Oliveira LC, Gupta S, Arbesú MG, Davoli M, Chan AKC, Mancuso ME.   +13 more
europepmc   +1 more source

A Shear Thickening Colloidal Suspension Functioning via Progressive Impact Jamming with Persistent Lubrication Layer

Advanced Science, EarlyView.
An ionic liquid‐based shear‐thickening fluid (ILSTF) exhibits lubricated dynamics from strong shear thickening to impact‐triggered jamming. A persistent nanometric solvation layer around silica governs both the shear thickening saturation in rheology and jamming front propagation under dynamic impact compression.
Yiran Wu, Yifeng Yu, Yiqiu Zhao, Qin Xu, T. X. Yu, Xin Zhang, Jinglei Yang   +6 more
wiley   +1 more source

From global guidelines for cardio-kidney-metabolic diseases management to national implementation: perspectives from the guideline workshop taskforce. [PDF]

Cardiovasc Diabetol
Wanner C, Cosentino F, Barnard-Kelly K, Battelino T, Blüher M, Boll HN, Brosius FC, Busetto L, Ceriello A, Gavin JR, Giorgino F, Green J, Ji L, Kellerer M, Koob S, Lalic N, Marx N, Nedungadi P, Parkin CG, Rodbard HW, Rydén L, Saboo B, Sheu WH, Standl E, Tacke F, Topsever P, Schnell O.   +26 more
europepmc   +1 more source

Neural Fields for Highly Accelerated 2D Cine Phase Contrast MRI

Advanced Science, EarlyView.
ABSTRACT 2D cine phase contrast (CPC) MRI provides quantitative information on blood velocity and flow within the human vasculature. However, data acquisition is time‐consuming, motivating the reconstruction of the velocity field from undersampled measurements to reduce scan times. In this work, neural fields are proposed as a continuous spatiotemporal
Pablo Arratia, Martin J. Graves, Mary McLean, Carolin Pirkl, Carola‐Bibiane Schönlieb, Timo Schirmer, Florian Wiesinger, Matthias J. Ehrhardt   +7 more
wiley   +1 more source

Random Neural Networks for Rough Volatility. [PDF]

Appl Math Optim
Jacquier A, Žurič Ž.
europepmc   +1 more source

High‐Resolution Multispectral Photovoltaic Imagers from Visible to Short‐Wave Infrared

Advanced Science, EarlyView.
We demonstrate a monolithic quad‐spectral imager that seamlessly integrates visible and short‐wave infrared detection on a single chip. Through direct photopatterning of an all‐polymer bulk heterojunction and colloidal quantum dots, the device achieves high‐resolution (640 × 512) imaging across 350–2400 nm, enabling multispectral capture for ...
Wanqing Li, Cheng Bi, Min He, Xiaolong Zheng, Yuning Luo, Yimei Tan, Chenxi Liu, Salihuojia Talanti, Yanfei Liu, Ge Mu, Qun Hao, Kangkang Weng, Xin Tang   +12 more
wiley   +1 more source

ESMO-ESTRO consensus statements on the safety of combining radiotherapy with EGFR, ALK, or BRAF/MEK inhibitors. [PDF]

ESMO Open
van Aken ESM, O'Cathail SM, Gandhi AK, Bussink J, Castelo-Branco L, Eriksen JG, Argilés G, Hiley CT, Atkinson V, Kaźmierska J, Calles A, Konopa K, Le Rhun E, McDonald F, Mountzios G, Putora PM, Muoio B, Ricardi U, Westphalen CB, Wrona A, Boot P, Pentheroudakis G, Belka C, Lordick F, Marijnen CAM, Martins-Branco D, De Ruysscher D, Barriuso J, Devnani B, de Jong MC, Prelaj A.   +30 more
europepmc   +1 more source