Results 41 to 50 of about 235,115 (280)

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

A robust crystal structure prediction method to support small molecule drug development with large scale validation and blind study

Nature Communications
Crystal polymorphism is an important and fascinating aspect of solid state chemistry with far reaching implications in the pharmaceuticals, agrisciences, nutraceuticals, battery and aviation industries.
Dong Zhou, Imanuel Bier, Biswajit Santra, Leif D. Jacobson, Chuanjie Wu, Adiran Garaizar Suarez, Barbara Ramirez Almaguer, Haoyu Yu, Robert Abel, Richard A. Friesner, Lingle Wang   +10 more
doaj   +1 more source

Artificial neural network prediction of the aluminum extraction from bauxite in the Bayer process [PDF]

Journal of the Serbian Chemical Society, 2012
This paper presents the results of statistical modeling of the bauxite leaching process, as part of Bayer technology for an alumina production.
Đurić Isidora, Mihajlović Ivan, Živković Živan   +2 more
doaj   +1 more source

Leaching Behavior of Lithium-Bearing Bauxite with High-Temperature Bayer Digestion Process in K₂O-Al₂O₃-H₂O System

Metals, 2021
Lithium is one of the secondary mineral elements occurring in bauxite. The behavior of lithium-bearing bauxite in the digestion process was investigated, and the effect of digestion conditions on the extraction rates of lithium was studied.
Dongzhan Han, Zhihong Peng, Erwei Song, Leiting Shen   +3 more
doaj   +1 more source

Bayer AG v. Housey Pharmaceuticals: Protection for Biotechnological Research Tools under Section 271(g) Found Wanting [PDF]

, 2005
[Excerpt] Research tools, a subset of biotechnological inventions protected by process patents, are “tools that scientists use in the laboratory, including cell lines, monoclonal antibodies, reagents, animal models, growth factors, combinatorial ...
Barthalow, Matthew
core   +1 more source

Longitudinal and transversal spin dynamics of donor-bound electrons in fluorine-doped ZnSe: spin inertia versus Hanle effect [PDF]

, 2015
The spin dynamics of the strongly localized, donor-bound electrons in fluorine-doped ZnSe epilayers is studied by pump-probe Kerr rotation techniques. A method exploiting the spin inertia is developed and used to measure the longitudinal spin relaxation ...
Bayer, M., Greilich, A., Heisterkamp, F., Korenev, V. L., Pawlis, A., Yakovlev, D. R., Zhukov, E. A.   +6 more
core   +2 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Creating product line architectures [PDF]

, 2000
The creation and validation of product line software architectures are inherently more complex than those of software architectures for single systems.
Bayer, J., Flege, O., Gacek, C.
core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Conflicting Views on Fair Siting Processes: Evidence from Austria and the U.S. [PDF]

, 1996
The authors maintain that, by granting legitimacy to different notions of fairness and building on common values such as responsibility, it is possible to design siting procedures that promote social cohesion, trust and a sense of fair ...
Fitzgerald, Kevin B., Linnerooth-Bayer, Joanne   +1 more
core   +1 more source