Results 41 to 50 of about 76,279 (263)

A Self-Consistent, High-Fidelity Adsorption Model for Chromatographic Process Predictions: Low-to-High Load Density and Charge Variants in a Preparative Cation Exchanger

Separations
The development of ion exchange chromatography to polish biopharmaceuticals requires extensive experimental benchmarking. As part of the Design of Experiments (DoE), statistical models increased efficiency somewhat and are still state of the art; however,
Gregor M. Essert, Marko Tesanovic, Sonja Berensmeier, Isabell Hagemann, Peter Schwan   +4 more
doaj   +1 more source

Estimation of Cleaning Efficiency of Clay Removal from Bauxite [PDF]

International Journal of Economic and Environment Geology, 2018
Bauxite ore is used as the raw material for the production of alumina in the Bayer hydrometallurgical process. Clay agglomerates on the bauxite surface create lot of complications in the Bayer process. Its concentration in the ore is decreased by washing
Ishaq Ahmad, Sajjad Hussain, Anwar Qadir, Naseer Muhammad Khan   +3 more
doaj  

Leaching Behavior of Lithium-Bearing Bauxite with High-Temperature Bayer Digestion Process in K₂O-Al₂O₃-H₂O System

Metals, 2021
Lithium is one of the secondary mineral elements occurring in bauxite. The behavior of lithium-bearing bauxite in the digestion process was investigated, and the effect of digestion conditions on the extraction rates of lithium was studied.
Dongzhan Han, Zhihong Peng, Erwei Song, Leiting Shen   +3 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

Molecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi, Stavros Makrodimitris, Sandra van Wilpe, Iris te Paske, Vanja de Weerd, Corine M. Beaufort, Hans M. Westgeest, Jens Voortman, Maureen J. B. Aarts, Maud Rijnders, Astrid A. M. van der Veldt, Ronald de Wit, Niven Mehra, Saskia M. Wilting, Debbie G. J. Robbrecht   +14 more
wiley   +1 more source

Processing of low-quality bauxite feedstock by thermochemistry-Bayer method

Записки Горного института, 2016
The modern production of aluminum which by its global output ranks first among the non-ferrous metals includes three main stages: ore extraction, its processing into alumina and, finally, the production of primary aluminum.
O. A. Dubovikov, E. E. Yaskelyainen
doaj   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Obtaining of transition phases of alumina starting from sodium aluminate in Bayer process [PDF]

Hemijska Industrija, 2011
Transition (active) phases of alumina were synthesized starting from sodium aluminate solution prepared out of Bayer liquor. The neutralisation of sodium aluminate solution was performed by sulphuric acid.
Obrenović Zoran, Filipović Radislav, Milanović Marija, Stijepović Ivan, Nikolić Ljubica M.   +4 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source