On the Prediction of pDNA Productivity Across Diverse Bioprocesses Using Ensemble Hybrid Models
Biotechnology and Bioengineering, EarlyView.ABSTRACT The global demand for plasmid DNA (pDNA) is rapidly increasing due to its key role in the manufacture of mRNA vaccines and advanced therapy medicinal products (ATMPs). However, the reliance on suboptimal batch and/or fed‐batch processes, as well as the diversity and increasing complexity of plasmid constructs pose significant challenges during
Nikolaos Stratis +2 more
wiley +1 more source
Reliability analysis of inverted exponentiated Rayleigh parameters via progressive hybrid censoring data with applications in medical data. [PDF]
PLoS OneNassr SG +5 more
europepmc +1 more source
Thermodynamic Evaluation of Dual Substrate Growth
Biotechnology and Bioengineering, EarlyView.ABSTRACT Various C₁–C₂ compounds are increasingly available through electrochemical reduction of CO2. Although not always suitable as a sole substrate, these compounds can supplement a primary substrate like glucose to enhance microbial growth. Yet, the mechanisms underlying the effects of dual substrate consumption on growth rate and growth yield ...
Marit A. Verheijen +3 more
wiley +1 more source
Bayesian estimation of the inverse Exponential Power distribution for COVID-19 case fatality analysis under SDG 3. [PDF]
Sci RepAkdam N +4 more
europepmc +1 more source
Model‐Enabled Knowledge Transfer Across Cell Lines, Culture Scales and Conditions
Biotechnology and Bioengineering, EarlyView.ABSTRACT Mechanistic models are central to quantitative understanding and optimization of Chinese hamster ovary (CHO) cell culture processes, but their utility is often restricted by parameter sets calibrated for specific cell lines, scales, or operating conditions.
Luxi Yu +2 more
wiley +1 more source
Bayes factor hypothesis testing in meta-analyses: Practical advantages and methodological considerations. [PDF]
Res Synth MethodsMulder J, van Aert RCM.
europepmc +1 more source
The influence of rivers on seabird foraging ecology
Biological Reviews, EarlyView.ABSTRACT Rivers act as vital arteries to the world's oceans, delivering fresh water and nutrients that sustain marine ecosystems. Globally, river flow increasingly is being altered by climate change and anthropogenic pressures; yet the significance of rivers to predatory marine species, such as seabirds, and the extent to which river‐related changes ...
Julia B. Morais +2 more
wiley +1 more source
Genuine learning biases persist after accounting for temporally decreasing learning rates: Insight from fitting six datasets. [PDF]
Proc Natl Acad Sci U S ACecchi R, Palminteri S.
europepmc +1 more source
How wildlife respond to tropical cyclones: short‐term tactics and long‐term impacts
Biological Reviews, EarlyView.ABSTRACT From butterflies to lizards and from sharks to seabirds, wildlife exhibit tactics to survive the impacts of tropical cyclones, also known as hurricanes, cyclones, or typhoons depending on where they occur. Some species seek refuge during the storm by moving, some remain in place and ride it out, and others move longer distances, avoiding the ...
Erin L. Koen +15 more
wiley +1 more source
Advances in causal discovery methods for ecological time series
Biological Reviews, EarlyView.ABSTRACT Recent advances in data collection technologies (e.g. automated sensor networks, satellite remote sensing, and high‐throughput sequencing) have greatly expanded the availability of ecological time series, enabling new opportunities for causal analyses in dynamic ecosystems.
Kenta Suzuki +6 more
wiley +1 more source