Results 81 to 90 of about 206,039 (334)
Analysis of the Use of Background Distribution for Naive Bayes Classifiers
Journal of Intelligent Systems, 2019 The naive Bayes classifier is a popular classifier, as it is easy to train, requires no cross-validation for parameter tuning, and can be easily extended due to its generative model. Moreover, recently it was shown that the word probabilities (background
Andrade Daniel +2 more
doaj +1 more source
An empirical Bayes estimation problem [PDF]
Proceedings of the National Academy of Sciences, 1980 Let x be a random variable such that, given θ, x is Poisson with mean θ, while θ has an unknown prior distribution G . In many statistical problems one wants to estimate as accurately as possible the parameter E (θǀ x =
openaire +2 more sources
Unraveling the Molecular Mechanisms Underlying Spontaneous Multipolar Mitosis Through CIN‐seq
Advanced Science, EarlyView.Multipolar mitosis, a hallmark of chromosomal instability (CIN), drives tumor heterogeneity but is challenging to study in live cells. Using CIN‐seq, a single‐cell multiomics method, we profiled rare CIN events and identified mechanisms associated with viable multipolar mitosis, including PTEN attenuation, Rho GTPase‐driven cytokinesis failure, and ...
Pin‐Rui Su +10 more
wiley +1 more source
An empirical Bayes mixture method for effect size and false discovery rate estimation
, 2010 Many statistical problems involve data from thousands of parallel cases. Each case has some associated effect size, and most cases will have no effect. It is often important to estimate the effect size and the local or tail-area false discovery rate for ...
Muralidharan, Omkar
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Advanced Science, EarlyView.ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao +11 more
wiley +1 more source
Sphingomonas paucimobilis‐Driven Epithelial–Endothelial Transition in Adenomyosis Pathogenesis
Advanced Science, EarlyView.This study identifies epithelial–endothelial transition (EET) as a novel adenomyosis pathogenic mechanism driven by Sphingomonas paucimobilis colonization. Systematic inhibitor experiments validate a TNFα→NF‐κB→MMP signaling cascade essential for EET. Critically, bacterial culture supernatant fails to induce pathological changes, demonstrating viable ...
Peigen Chen +7 more
wiley +1 more source
Austrian Journal of Statistics, 2018 In this article, estimation of stress-strength reliability $\delta=P\left ...
Hare Krishna, Madhulika Dube, Renu Garg
doaj +1 more source
An assessment of empirical Bayes and composite estimators for small areas [PDF]
We compare a set of empirical Bayes and composite estimators of the population means of the districts (small areas) of a country, and show that the natural modelling strategy of searching for a well fitting empirical Bayes model and using it for ...
Nicholas Longford
core
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that maternal antibiotic exposure prior to conception disrupts intergenerational gut microbial succession. By enhancing maternal‐offspring microbial transmission, altering microbial developmental trajectories and increasing selective pressures during community assembly, these disturbances lead to persistent gut mucosal immaturity and
Yuzhu Chen +8 more
wiley +1 more source